Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950214900> ?p ?o ?g. }
- W2950214900 endingPage "1180" @default.
- W2950214900 startingPage "1169" @default.
- W2950214900 abstract "Abstract The incidence of skeletal anomalies in reared fish has been translated for years in important economic losses for the aquaculture industry. In the present study, we have analysed the gene expression of extracellular matrix components and transcription factors involved in bone development in gilthead sea bream presenting different skeletal anomalies: lordosis (LD), lordosis–scoliosis–kyphosis (LSK) or opercular, dental or jaw malformations in comparison with control (CT) specimens. Results showed a possible link between the presence of LD and LSK and the significant downregulation of genes involved in osteoblasts' maturation and matrix mineralization (collagen type 1‐alpha, osteopontin, osteocalcin, matrix Gla protein and tissue non‐specific alkaline phosphatase), as well as in bone resorption (cathepsin K and matrix metalloproteinase 9) compared to CT animals. Contrarily, the key osteogenic transcription factor runx2 was upregulated in the malformed vertebra suggesting impaired determination of mesenchymal stem cells towards the osteoblastic lineage. Despite the gene expression patterns of the other malformed structures were not affected in comparison with CT fish, the results of the present study may contribute in the long term to identify potential candidate gene profiles associated with column deformities that may help reducing the incidence of appearance of skeletal anomalies in this important aquaculture species." @default.
- W2950214900 created "2019-06-27" @default.
- W2950214900 creator A5006030183 @default.
- W2950214900 creator A5030104251 @default.
- W2950214900 creator A5043236697 @default.
- W2950214900 creator A5070596308 @default.
- W2950214900 creator A5085088934 @default.
- W2950214900 date "2019-06-10" @default.
- W2950214900 modified "2023-10-17" @default.
- W2950214900 title "Gene expression analyses in malformed skeletal structures of gilthead sea bream (<i>Sparus aurata</i>)" @default.
- W2950214900 cites W1504230687 @default.
- W2950214900 cites W1529546420 @default.
- W2950214900 cites W1835985531 @default.
- W2950214900 cites W1970695554 @default.
- W2950214900 cites W1971374077 @default.
- W2950214900 cites W1973340252 @default.
- W2950214900 cites W1975300051 @default.
- W2950214900 cites W1976224611 @default.
- W2950214900 cites W1976571762 @default.
- W2950214900 cites W1990783813 @default.
- W2950214900 cites W1990937975 @default.
- W2950214900 cites W1993163916 @default.
- W2950214900 cites W1996058081 @default.
- W2950214900 cites W2001787405 @default.
- W2950214900 cites W2003764346 @default.
- W2950214900 cites W2004297307 @default.
- W2950214900 cites W2017782730 @default.
- W2950214900 cites W2024152221 @default.
- W2950214900 cites W2028421282 @default.
- W2950214900 cites W2031457097 @default.
- W2950214900 cites W2035934212 @default.
- W2950214900 cites W2038027702 @default.
- W2950214900 cites W2045126335 @default.
- W2950214900 cites W2050758257 @default.
- W2950214900 cites W2055573396 @default.
- W2950214900 cites W2056502535 @default.
- W2950214900 cites W2059470587 @default.
- W2950214900 cites W2063071273 @default.
- W2950214900 cites W2069641334 @default.
- W2950214900 cites W2071780635 @default.
- W2950214900 cites W2077739744 @default.
- W2950214900 cites W2085280095 @default.
- W2950214900 cites W2085793041 @default.
- W2950214900 cites W2086617432 @default.
- W2950214900 cites W2088366255 @default.
- W2950214900 cites W2102849968 @default.
- W2950214900 cites W2108244474 @default.
- W2950214900 cites W2110143910 @default.
- W2950214900 cites W2117266606 @default.
- W2950214900 cites W2121312756 @default.
- W2950214900 cites W2121780717 @default.
- W2950214900 cites W2123501262 @default.
- W2950214900 cites W2125557975 @default.
- W2950214900 cites W2126537537 @default.
- W2950214900 cites W2132040456 @default.
- W2950214900 cites W2139055053 @default.
- W2950214900 cites W2142524309 @default.
- W2950214900 cites W2153734062 @default.
- W2950214900 cites W2168420558 @default.
- W2950214900 cites W2248965453 @default.
- W2950214900 cites W2274739255 @default.
- W2950214900 cites W2319041222 @default.
- W2950214900 cites W2431992247 @default.
- W2950214900 cites W2733735181 @default.
- W2950214900 cites W2737573026 @default.
- W2950214900 cites W2884396031 @default.
- W2950214900 cites W2942494084 @default.
- W2950214900 doi "https://doi.org/10.1111/jfd.13019" @default.
- W2950214900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31180144" @default.
- W2950214900 hasPublicationYear "2019" @default.
- W2950214900 type Work @default.
- W2950214900 sameAs 2950214900 @default.
- W2950214900 citedByCount "7" @default.
- W2950214900 countsByYear W29502149002020 @default.
- W2950214900 countsByYear W29502149002021 @default.
- W2950214900 countsByYear W29502149002022 @default.
- W2950214900 countsByYear W29502149002023 @default.
- W2950214900 crossrefType "journal-article" @default.
- W2950214900 hasAuthorship W2950214900A5006030183 @default.
- W2950214900 hasAuthorship W2950214900A5030104251 @default.
- W2950214900 hasAuthorship W2950214900A5043236697 @default.
- W2950214900 hasAuthorship W2950214900A5070596308 @default.
- W2950214900 hasAuthorship W2950214900A5085088934 @default.
- W2950214900 hasConcept C101990758 @default.
- W2950214900 hasConcept C104317684 @default.
- W2950214900 hasConcept C105702510 @default.
- W2950214900 hasConcept C126322002 @default.
- W2950214900 hasConcept C127561419 @default.
- W2950214900 hasConcept C131075544 @default.
- W2950214900 hasConcept C134018914 @default.
- W2950214900 hasConcept C146562846 @default.
- W2950214900 hasConcept C150194340 @default.
- W2950214900 hasConcept C160160445 @default.
- W2950214900 hasConcept C181199279 @default.
- W2950214900 hasConcept C189165786 @default.
- W2950214900 hasConcept C198826908 @default.
- W2950214900 hasConcept C202751555 @default.
- W2950214900 hasConcept C2776033226 @default.