Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950215543> ?p ?o ?g. }
- W2950215543 endingPage "7552" @default.
- W2950215543 startingPage "7540" @default.
- W2950215543 abstract "The total synthesis of the marine macrolide bryostatin 2 is described. The synthesis plan relies on aldol and directed reduction steps in order to construct the anti-1,3-diol array present in each of the principal subunits (A, B, and C). These fragments were coupled using a Julia olefination and subsequent sulfone alkylation. A series of functionalization reactions provided a bryopyran seco acid, which was macrolactonized under Yamaguchi conditions. Installation of the two enoate moieties took advantage of asymmetric phosphonate and aldol condensation strategies. Reduction of the C20 ketone and simple protecting group operations then completed the synthesis of bryostatin 2. This flexible approach should provide access to a series of new analogues of this clinically important marine natural product." @default.
- W2950215543 created "2019-06-27" @default.
- W2950215543 creator A5005122260 @default.
- W2950215543 creator A5026261263 @default.
- W2950215543 creator A5035782410 @default.
- W2950215543 creator A5044555614 @default.
- W2950215543 creator A5049997686 @default.
- W2950215543 creator A5083769956 @default.
- W2950215543 date "1999-08-01" @default.
- W2950215543 modified "2023-10-11" @default.
- W2950215543 title "Total Synthesis of Bryostatin 2" @default.
- W2950215543 cites W110527313 @default.
- W2950215543 cites W1966691535 @default.
- W2950215543 cites W1968479888 @default.
- W2950215543 cites W1972228069 @default.
- W2950215543 cites W1978621290 @default.
- W2950215543 cites W1983338160 @default.
- W2950215543 cites W1983921082 @default.
- W2950215543 cites W1987026350 @default.
- W2950215543 cites W1988013438 @default.
- W2950215543 cites W1990658138 @default.
- W2950215543 cites W1991700756 @default.
- W2950215543 cites W2003120439 @default.
- W2950215543 cites W2007069751 @default.
- W2950215543 cites W2020408576 @default.
- W2950215543 cites W2022412731 @default.
- W2950215543 cites W2024051324 @default.
- W2950215543 cites W2025173654 @default.
- W2950215543 cites W2031799240 @default.
- W2950215543 cites W2038758108 @default.
- W2950215543 cites W2038905259 @default.
- W2950215543 cites W2042994847 @default.
- W2950215543 cites W2043080982 @default.
- W2950215543 cites W2049179050 @default.
- W2950215543 cites W2050291163 @default.
- W2950215543 cites W2054489385 @default.
- W2950215543 cites W2056491853 @default.
- W2950215543 cites W2060936753 @default.
- W2950215543 cites W2061496844 @default.
- W2950215543 cites W2068678032 @default.
- W2950215543 cites W2068863429 @default.
- W2950215543 cites W2069723308 @default.
- W2950215543 cites W2069873423 @default.
- W2950215543 cites W2071495883 @default.
- W2950215543 cites W2072401650 @default.
- W2950215543 cites W2082036649 @default.
- W2950215543 cites W2092344343 @default.
- W2950215543 cites W2094546664 @default.
- W2950215543 cites W2104834142 @default.
- W2950215543 cites W2108500002 @default.
- W2950215543 cites W2116403966 @default.
- W2950215543 cites W2137430503 @default.
- W2950215543 cites W2140879800 @default.
- W2950215543 cites W2275165869 @default.
- W2950215543 cites W2343335392 @default.
- W2950215543 cites W2415372781 @default.
- W2950215543 cites W2949307251 @default.
- W2950215543 cites W2950718588 @default.
- W2950215543 cites W2951059818 @default.
- W2950215543 cites W2952695496 @default.
- W2950215543 cites W3004878107 @default.
- W2950215543 cites W82364718 @default.
- W2950215543 doi "https://doi.org/10.1021/ja990860j" @default.
- W2950215543 hasPublicationYear "1999" @default.
- W2950215543 type Work @default.
- W2950215543 sameAs 2950215543 @default.
- W2950215543 citedByCount "242" @default.
- W2950215543 countsByYear W29502155432012 @default.
- W2950215543 countsByYear W29502155432013 @default.
- W2950215543 countsByYear W29502155432014 @default.
- W2950215543 countsByYear W29502155432015 @default.
- W2950215543 countsByYear W29502155432016 @default.
- W2950215543 countsByYear W29502155432017 @default.
- W2950215543 countsByYear W29502155432018 @default.
- W2950215543 countsByYear W29502155432019 @default.
- W2950215543 countsByYear W29502155432020 @default.
- W2950215543 countsByYear W29502155432021 @default.
- W2950215543 countsByYear W29502155432022 @default.
- W2950215543 countsByYear W29502155432023 @default.
- W2950215543 crossrefType "journal-article" @default.
- W2950215543 hasAuthorship W2950215543A5005122260 @default.
- W2950215543 hasAuthorship W2950215543A5026261263 @default.
- W2950215543 hasAuthorship W2950215543A5035782410 @default.
- W2950215543 hasAuthorship W2950215543A5044555614 @default.
- W2950215543 hasAuthorship W2950215543A5049997686 @default.
- W2950215543 hasAuthorship W2950215543A5083769956 @default.
- W2950215543 hasConcept C161790260 @default.
- W2950215543 hasConcept C164361826 @default.
- W2950215543 hasConcept C178790620 @default.
- W2950215543 hasConcept C181199279 @default.
- W2950215543 hasConcept C185592680 @default.
- W2950215543 hasConcept C18616679 @default.
- W2950215543 hasConcept C195794163 @default.
- W2950215543 hasConcept C21951064 @default.
- W2950215543 hasConcept C2777626080 @default.
- W2950215543 hasConcept C2777738585 @default.
- W2950215543 hasConcept C2779396153 @default.
- W2950215543 hasConcept C2779746882 @default.