FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950231046> ?p ?o ?g. }

• W2950231046 endingPage "857" @default.
• W2950231046 startingPage "849" @default.
• W2950231046 abstract "We first examined the relation between the induction of glutathione and immune functions in mice after low-dose γ-ray irradiation. Thereafter, inhibition of tumor growth by radiation was confirmed in Ehrlich solid tumor (EST)-bearing mice. The total glutathione level of the splenocytes transiently increased soon after irradiation and reached a maximum at around 4 h postirradiation. Thereafter, the level reverted to the 0 h value by 24 h postirradiation. A significantly high splenocyte proliferative response was also recognized 4 h postirradiation. Natural killer (NK) activity was also increased significantly in a similar manner. The time at which the response reached the maximum coincided well with that of maximum total glutathione levels of the splenocytes in the γ-ray-irradiated mice. Reduced glutathione exogenously added to splenocytes obtained from normal mice enhanced the proliferative response and NK activity in a dose-dependent manner. The inhibitory effects of radiation on tumor growth was then examined in EST-bearing mice. Repeated low-dose irradiation (0.5 Gy, four times, before and within an early time after inoculation) significantly delayed the tumor growth. Finally, the effect of single low-dose (0.5 Gy), whole-body γ-ray irradiation on immune balance was examined to elucidate the mechanism underlying the antitumor immunity. The percentage of B cells in blood lymphocytes was selectively decreased after radiation, concomitant with an increase in that of the helper T cell population. The IFN-γ level in splenocyte culture prepared from EST-bearing mice was significantly increased 48 h after radiation, although the level of IL-4 was unchanged. IL-12 secretion from macrophages was also enhanced by radiation. These results suggest that low-dose γ-rays induce Th1 polarization and enhance the activities of tumoricidal effector cells, leading to an inhibition of tumor growth." @default.
• W2950231046 created "2019-06-27" @default.
• W2950231046 creator A5037779364 @default.
• W2950231046 date "2006-10-01" @default.
• W2950231046 modified "2023-10-06" @default.
• W2950231046 title "Induction of Glutathione and Activation of Immune Functions by Low-dose, Whole-body Irradiation with γ-Rays" @default.
• W2950231046 cites W1500207531 @default.
• W2950231046 cites W1580210576 @default.
• W2950231046 cites W1600359323 @default.
• W2950231046 cites W1942668068 @default.
• W2950231046 cites W1965715262 @default.
• W2950231046 cites W1966099651 @default.
• W2950231046 cites W1966333025 @default.
• W2950231046 cites W1974486772 @default.
• W2950231046 cites W1982093100 @default.
• W2950231046 cites W1986655901 @default.
• W2950231046 cites W1995631681 @default.
• W2950231046 cites W2012960886 @default.
• W2950231046 cites W2015837920 @default.
• W2950231046 cites W2017953304 @default.
• W2950231046 cites W2025309264 @default.
• W2950231046 cites W2027749164 @default.
• W2950231046 cites W2042790563 @default.
• W2950231046 cites W2057039118 @default.
• W2950231046 cites W2059679982 @default.
• W2950231046 cites W2060293402 @default.
• W2950231046 cites W2061545951 @default.
• W2950231046 cites W2064476022 @default.
• W2950231046 cites W2065533784 @default.
• W2950231046 cites W2066281890 @default.
• W2950231046 cites W2076465102 @default.
• W2950231046 cites W2083468617 @default.
• W2950231046 cites W2085384888 @default.
• W2950231046 cites W2089820030 @default.
• W2950231046 cites W2107252861 @default.
• W2950231046 cites W2129889907 @default.
• W2950231046 cites W2132789753 @default.
• W2950231046 cites W2135281242 @default.
• W2950231046 cites W2138733343 @default.
• W2950231046 cites W2155749150 @default.
• W2950231046 cites W2157986513 @default.
• W2950231046 cites W2164322090 @default.
• W2950231046 cites W2168852857 @default.
• W2950231046 cites W2171282314 @default.
• W2950231046 cites W4245957869 @default.
• W2950231046 doi "https://doi.org/10.1248/yakushi.126.849" @default.
• W2950231046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17016016" @default.
• W2950231046 hasPublicationYear "2006" @default.
• W2950231046 type Work @default.
• W2950231046 sameAs 2950231046 @default.
• W2950231046 citedByCount "15" @default.
• W2950231046 countsByYear W29502310462012 @default.
• W2950231046 countsByYear W29502310462013 @default.
• W2950231046 countsByYear W29502310462015 @default.
• W2950231046 countsByYear W29502310462016 @default.
• W2950231046 countsByYear W29502310462017 @default.
• W2950231046 countsByYear W29502310462018 @default.
• W2950231046 countsByYear W29502310462022 @default.
• W2950231046 countsByYear W29502310462023 @default.
• W2950231046 crossrefType "journal-article" @default.
• W2950231046 hasAuthorship W2950231046A5037779364 @default.
• W2950231046 hasBestOaLocation W29502310461 @default.
• W2950231046 hasConcept C126322002 @default.
• W2950231046 hasConcept C134018914 @default.
• W2950231046 hasConcept C181199279 @default.
• W2950231046 hasConcept C185592680 @default.
• W2950231046 hasConcept C189976730 @default.
• W2950231046 hasConcept C203014093 @default.
• W2950231046 hasConcept C2908647359 @default.
• W2950231046 hasConcept C538909803 @default.
• W2950231046 hasConcept C55493867 @default.
• W2950231046 hasConcept C71924100 @default.
• W2950231046 hasConcept C86803240 @default.
• W2950231046 hasConcept C8891405 @default.
• W2950231046 hasConcept C99454951 @default.
• W2950231046 hasConceptScore W2950231046C126322002 @default.
• W2950231046 hasConceptScore W2950231046C134018914 @default.
• W2950231046 hasConceptScore W2950231046C181199279 @default.
• W2950231046 hasConceptScore W2950231046C185592680 @default.
• W2950231046 hasConceptScore W2950231046C189976730 @default.
• W2950231046 hasConceptScore W2950231046C203014093 @default.
• W2950231046 hasConceptScore W2950231046C2908647359 @default.
• W2950231046 hasConceptScore W2950231046C538909803 @default.
• W2950231046 hasConceptScore W2950231046C55493867 @default.
• W2950231046 hasConceptScore W2950231046C71924100 @default.
• W2950231046 hasConceptScore W2950231046C86803240 @default.
• W2950231046 hasConceptScore W2950231046C8891405 @default.
• W2950231046 hasConceptScore W2950231046C99454951 @default.
• W2950231046 hasIssue "10" @default.
• W2950231046 hasLocation W29502310461 @default.
• W2950231046 hasLocation W29502310462 @default.
• W2950231046 hasOpenAccess W2950231046 @default.
• W2950231046 hasPrimaryLocation W29502310461 @default.
• W2950231046 hasRelatedWork W1966504330 @default.
• W2950231046 hasRelatedWork W1979139803 @default.
• W2950231046 hasRelatedWork W1996874733 @default.
• W2950231046 hasRelatedWork W2030889776 @default.
• W2950231046 hasRelatedWork W2037631372 @default.

• next