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• W2950240087 abstract "Introduction: Initial evaluation and staging of patients with Hodgkin lymphoma (HL) provides the foundation for formulation of a risk-adapted treatment plan. The Ann Arbor staging system at first, and later the Cotswolds modifications criteria, have helped classify patients into risk groups according to the distribution and number of anatomic sites of disease. As imaging has evolved over the years fewer invasive measures (laparotomy with splenectomy or bone marrow biopsies) are required to determine involved sites. However, radiologic advances have created new challenges as they allow for volumetric measurements of disease; factors such as “bulk” disease are now prognostic and part of staging. Further refinements to the staging of patients with HL are needed to allow for improved prognostication and assignment to risk groups. While the treatment regimens for pediatric Hodgkin lymphoma have somewhat differed from that of adults with a goal to minimize late-effects and specific cumulative drug dosages for this young and surviving population, the staging is the same as for adults. Methods: The International SEARCH (Staging, Evaluation and Response Criteria Harmonization) for CAYAHL (Childhood, Adolescent and Young Adult Hodgkin Lymphoma) group is comprised of representatives from the Children's Oncology Group, European Network for Pediatric HL, St. Jude-Stanford-Dana-Farber consortium, and the Asociación de Hemato-Oncología Pediátrica de Centro América to facilitate the interpretation and comparison of clinical studies worldwide. As we look ahead to potential changes in the staging of HL, we feel it is important to ensure pediatric representation from the SEARCH for CAYAHL group. Given that adolescent and young adult patients are a known peak age range for HL and shared between the adult and pediatric groups, the more unified the staging remains across all age ranges, the better patient outcomes can be compared between trials and inform decision-making. In an era where positron emission tomography scans are the standard for initial staging work up, many new strategies such as the utilization of total metabolic tumor volume, may provide an improved methodology for staging. Conclusion: As the field of HL moves forward, initial staging is an evolving process. Despite differences in the treatment of pediatric and adult patients with HL there is a need to ensure consistency in the staging between the groups. The SEARCH for CAYAHL working group has representation from all major pediatric consortia and should work together with colleagues from the adult groups towards a common goal and vision for the establishment of new staging criteria. Keywords: Hodgkin lymphoma (HL); positron emission tomography (PET)." @default.
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• W2950240087 date "2019-06-01" @default.
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• W2950240087 title "INCLUSION OF A PEDIATRIC PERSPECTIVE INTO RECOMMENDATIONS FOR THE INITIAL EVALUATION AND STAGING OF HODGKIN LYMPHOMA: A CALL TO ACTION FROM THE INTERNATIONAL SEARCH WORKING GROUP" @default.
• W2950240087 doi "https://doi.org/10.1002/hon.24_2629" @default.
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