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• W2950245811 abstract "Microtubules are dynamic polymers, which grow and shrink by addition and removal of tubulin dimers at their extremities. Within the microtubule shaft, dimers adopt a densely packed and highly ordered crystal-like lattice structure, which is generally not considered to be dynamic. Here, we report that thermal forces are sufficient to remodel the microtubule shaft, despite its apparent stability. Our combined experimental data and numerical simulations on lattice dynamics and structure suggest that dimers can spontaneously leave and be incorporated into the lattice at structural defects. We propose a model mechanism, where the lattice dynamics is initiated via a passive breathing mechanism at dislocations, which are frequent in rapidly growing microtubules. These results show that we may need to extend the concept of dissipative dynamics, previously established for microtubule extremities, to the entire shaft, instead of considering it as a passive material. Microtubules vary their length by gaining and shedding tubulin dimers dynamically at both ends. But evidence now suggests that dimers may also be incorporated into the middle of the shaft—calling into question existing models of growth dynamics." @default.
• W2950245811 created "2019-06-27" @default.
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• W2950245811 date "2019-06-03" @default.
• W2950245811 modified "2023-10-11" @default.
• W2950245811 title "Lattice defects induce microtubule self-renewal" @default.
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• W2950245811 doi "https://doi.org/10.1038/s41567-019-0542-4" @default.
• W2950245811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6924994" @default.
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• W2950245811 hasPublicationYear "2019" @default.
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