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- W2950246413 abstract "The objective of this brief review is to present an overview of the bioorganic chemistry of cyclic-ADP-ribose (cADPR) with special emphasis on the methodology used for the synthesis of analogues of cADPR. New structural analogues of cADPR can be prepared using either the biomimetic method or ADP-ribosyl cyclase from Aplysia californica. For the most part, both procedures give similar product profiles, but higher yields are generally obtained with the enzymatic method. These synthetic methodologies have allowed the transformation of a variety of structurally modified analogues of NAD+ into their corresponding cyclic nucleotides. Several of these novel analogues are more potent than cADPR in inducing calcium release and are also more stable towards degradative enzymes. They could serve as valuable affinity probes for the isolation of cADPR-binding proteins." @default.
- W2950246413 created "2019-06-27" @default.
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- W2950246413 date "1999-05-01" @default.
- W2950246413 modified "2023-10-14" @default.
- W2950246413 title "Bioorganic chemistry of cyclic ADP-ribose (cADPR)1In memory of Sir Derek H. R. Barton, 1918–1998.1" @default.
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- W2950246413 doi "https://doi.org/10.1016/s0968-0896(98)00256-9" @default.
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