Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950249582> ?p ?o ?g. }
- W2950249582 abstract "The robust axonal growth and regenerative capacities of young neurons decrease substantially with age. This developmental downregulation of axonal growth may facilitate axonal pruning and neural circuit formation but limits functional recovery following nerve damage. While external factors influencing axonal growth have been extensively investigated, relatively little is known about the intrinsic molecular changes underlying the age-dependent reduction in regeneration capacity. We report that developmental downregulation of LIS1 is responsible for the decreased axonal extension capacity of mature dorsal root ganglion (DRG) neurons. In contrast, exogenous LIS1 expression or endogenous LIS1 augmentation by calpain inhibition restored axonal extension capacity in mature DRG neurons and facilitated regeneration of the damaged sciatic nerve. The insulator protein CTCF suppressed LIS1 expression in mature DRG neurons, and this reduction resulted in excessive accumulation of phosphoactivated GSK-3β at the axon tip, causing failure of the axonal extension. Conversely, sustained LIS1 expression inhibited developmental axon pruning in the mammillary body. Thus, LIS1 regulation may coordinate the balance between axonal growth and pruning during maturation of neuronal circuits." @default.
- W2950249582 created "2019-06-27" @default.
- W2950249582 creator A5020317497 @default.
- W2950249582 creator A5024119860 @default.
- W2950249582 creator A5040530002 @default.
- W2950249582 creator A5069360562 @default.
- W2950249582 creator A5074765442 @default.
- W2950249582 creator A5079850659 @default.
- W2950249582 date "2017-01-01" @default.
- W2950249582 modified "2023-09-24" @default.
- W2950249582 title "Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning" @default.
- W2950249582 cites W1518972222 @default.
- W2950249582 cites W1580418835 @default.
- W2950249582 cites W1600079321 @default.
- W2950249582 cites W1655643580 @default.
- W2950249582 cites W1956978115 @default.
- W2950249582 cites W1977555575 @default.
- W2950249582 cites W1980438916 @default.
- W2950249582 cites W1984827465 @default.
- W2950249582 cites W1985705162 @default.
- W2950249582 cites W1986552075 @default.
- W2950249582 cites W1990019976 @default.
- W2950249582 cites W1992502425 @default.
- W2950249582 cites W1996323021 @default.
- W2950249582 cites W2000620031 @default.
- W2950249582 cites W2010124105 @default.
- W2950249582 cites W2013049558 @default.
- W2950249582 cites W2017400430 @default.
- W2950249582 cites W2017929785 @default.
- W2950249582 cites W2024327273 @default.
- W2950249582 cites W2029643611 @default.
- W2950249582 cites W2030291352 @default.
- W2950249582 cites W2037110185 @default.
- W2950249582 cites W2039252375 @default.
- W2950249582 cites W2042776153 @default.
- W2950249582 cites W2048121649 @default.
- W2950249582 cites W2048787376 @default.
- W2950249582 cites W2050359676 @default.
- W2950249582 cites W2050935187 @default.
- W2950249582 cites W2056273108 @default.
- W2950249582 cites W2067340269 @default.
- W2950249582 cites W2068156633 @default.
- W2950249582 cites W2071046573 @default.
- W2950249582 cites W2075783807 @default.
- W2950249582 cites W2084080552 @default.
- W2950249582 cites W2086694643 @default.
- W2950249582 cites W2087454952 @default.
- W2950249582 cites W2100728233 @default.
- W2950249582 cites W2102354182 @default.
- W2950249582 cites W2115850825 @default.
- W2950249582 cites W2119143172 @default.
- W2950249582 cites W2120696154 @default.
- W2950249582 cites W2121854884 @default.
- W2950249582 cites W2131673631 @default.
- W2950249582 cites W2134861134 @default.
- W2950249582 cites W2139074300 @default.
- W2950249582 cites W2141435782 @default.
- W2950249582 cites W2150380320 @default.
- W2950249582 cites W2157786925 @default.
- W2950249582 cites W2162117855 @default.
- W2950249582 cites W2166629347 @default.
- W2950249582 cites W2169536231 @default.
- W2950249582 cites W2171231804 @default.
- W2950249582 cites W2415110637 @default.
- W2950249582 cites W4229924429 @default.
- W2950249582 cites W4249168173 @default.
- W2950249582 doi "https://doi.org/10.1242/bio.025999" @default.
- W2950249582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5550919" @default.
- W2950249582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28630356" @default.
- W2950249582 hasPublicationYear "2017" @default.
- W2950249582 type Work @default.
- W2950249582 sameAs 2950249582 @default.
- W2950249582 citedByCount "5" @default.
- W2950249582 countsByYear W29502495822018 @default.
- W2950249582 countsByYear W29502495822021 @default.
- W2950249582 countsByYear W29502495822023 @default.
- W2950249582 crossrefType "journal-article" @default.
- W2950249582 hasAuthorship W2950249582A5020317497 @default.
- W2950249582 hasAuthorship W2950249582A5024119860 @default.
- W2950249582 hasAuthorship W2950249582A5040530002 @default.
- W2950249582 hasAuthorship W2950249582A5069360562 @default.
- W2950249582 hasAuthorship W2950249582A5074765442 @default.
- W2950249582 hasAuthorship W2950249582A5079850659 @default.
- W2950249582 hasBestOaLocation W29502495821 @default.
- W2950249582 hasConcept C104317684 @default.
- W2950249582 hasConcept C127561419 @default.
- W2950249582 hasConcept C169760540 @default.
- W2950249582 hasConcept C171056886 @default.
- W2950249582 hasConcept C2776281502 @default.
- W2950249582 hasConcept C2779530196 @default.
- W2950249582 hasConcept C2780775167 @default.
- W2950249582 hasConcept C55493867 @default.
- W2950249582 hasConcept C70192387 @default.
- W2950249582 hasConcept C86803240 @default.
- W2950249582 hasConcept C95444343 @default.
- W2950249582 hasConceptScore W2950249582C104317684 @default.
- W2950249582 hasConceptScore W2950249582C127561419 @default.
- W2950249582 hasConceptScore W2950249582C169760540 @default.
- W2950249582 hasConceptScore W2950249582C171056886 @default.
- W2950249582 hasConceptScore W2950249582C2776281502 @default.