Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950250770> ?p ?o ?g. }
- W2950250770 endingPage "1280" @default.
- W2950250770 startingPage "1271" @default.
- W2950250770 abstract "The spectre of the coming post-antibiotic age demands novel therapies for infectious diseases. Tuberculosis (TB), caused by Mycobacterium tuberculosis, is the single deadliest infection throughout human history. M. tuberculosis has acquired antibiotic resistance at an alarming rate with some strains reported as being totally drug resistant. Host-directed therapies (HDTs) attempt to overcome the evolution of antibiotic resistance by targeting relatively immutable host processes. Here, I hypothesise the induction of hypoxia via anti-angiogenic therapy will be an efficacious HDT against TB. I argue that anti-angiogenic therapy is a modernisation of industrial revolution era sanatoria treatment for TB, and present a view of the TB granuloma as a 'bacterial tumour' that can be treated with anti-angiogenic therapies to reduce bacterial burden and spare host immunopathology. I suggest two complementary modes of action, induction of bacterial dormancy and activation of host hypoxia-induced factor (HIF)-mediated immunity, and define the experimental tools necessary to test this hypothesis." @default.
- W2950250770 created "2019-06-27" @default.
- W2950250770 creator A5057736752 @default.
- W2950250770 date "2019-06-01" @default.
- W2950250770 modified "2023-10-18" @default.
- W2950250770 title "Revisiting hypoxia therapies for tuberculosis" @default.
- W2950250770 cites W1508317931 @default.
- W2950250770 cites W1510711119 @default.
- W2950250770 cites W1937479869 @default.
- W2950250770 cites W1969055840 @default.
- W2950250770 cites W1970610212 @default.
- W2950250770 cites W1973441038 @default.
- W2950250770 cites W1993191750 @default.
- W2950250770 cites W1995869727 @default.
- W2950250770 cites W2000621264 @default.
- W2950250770 cites W2000710967 @default.
- W2950250770 cites W2009682592 @default.
- W2950250770 cites W2015609239 @default.
- W2950250770 cites W2017082814 @default.
- W2950250770 cites W2018396843 @default.
- W2950250770 cites W2021947467 @default.
- W2950250770 cites W2040584799 @default.
- W2950250770 cites W2051139401 @default.
- W2950250770 cites W2056521763 @default.
- W2950250770 cites W2060245069 @default.
- W2950250770 cites W2063593097 @default.
- W2950250770 cites W2067443873 @default.
- W2950250770 cites W2071723955 @default.
- W2950250770 cites W2075271267 @default.
- W2950250770 cites W2078490888 @default.
- W2950250770 cites W2080162976 @default.
- W2950250770 cites W2080420984 @default.
- W2950250770 cites W2086565225 @default.
- W2950250770 cites W2095451731 @default.
- W2950250770 cites W2097068673 @default.
- W2950250770 cites W2097144541 @default.
- W2950250770 cites W2099929652 @default.
- W2950250770 cites W2104048810 @default.
- W2950250770 cites W2105296171 @default.
- W2950250770 cites W2108422091 @default.
- W2950250770 cites W2127549894 @default.
- W2950250770 cites W2139012536 @default.
- W2950250770 cites W2140811485 @default.
- W2950250770 cites W2140956735 @default.
- W2950250770 cites W2141166469 @default.
- W2950250770 cites W2143036691 @default.
- W2950250770 cites W2146193668 @default.
- W2950250770 cites W2150037895 @default.
- W2950250770 cites W2152575141 @default.
- W2950250770 cites W2161458072 @default.
- W2950250770 cites W2166333921 @default.
- W2950250770 cites W2168066272 @default.
- W2950250770 cites W2168152179 @default.
- W2950250770 cites W2169736119 @default.
- W2950250770 cites W2171338169 @default.
- W2950250770 cites W2183472088 @default.
- W2950250770 cites W2269987302 @default.
- W2950250770 cites W2301810819 @default.
- W2950250770 cites W2327020748 @default.
- W2950250770 cites W2329233897 @default.
- W2950250770 cites W2338553404 @default.
- W2950250770 cites W2409670633 @default.
- W2950250770 cites W2423696935 @default.
- W2950250770 cites W2478985445 @default.
- W2950250770 cites W2516972459 @default.
- W2950250770 cites W2519569616 @default.
- W2950250770 cites W2521314797 @default.
- W2950250770 cites W2538911713 @default.
- W2950250770 cites W2547156322 @default.
- W2950250770 cites W2554785108 @default.
- W2950250770 cites W2569716634 @default.
- W2950250770 cites W2592038016 @default.
- W2950250770 cites W2606355764 @default.
- W2950250770 cites W2791778287 @default.
- W2950250770 cites W2793935598 @default.
- W2950250770 cites W2800598167 @default.
- W2950250770 cites W2802693280 @default.
- W2950250770 cites W2806036035 @default.
- W2950250770 cites W2883562274 @default.
- W2950250770 cites W2897806529 @default.
- W2950250770 cites W2901109511 @default.
- W2950250770 cites W2921127352 @default.
- W2950250770 cites W2940318022 @default.
- W2950250770 cites W2946674780 @default.
- W2950250770 cites W3023485107 @default.
- W2950250770 cites W4250428608 @default.
- W2950250770 doi "https://doi.org/10.1042/cs20190415" @default.
- W2950250770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31209098" @default.
- W2950250770 hasPublicationYear "2019" @default.
- W2950250770 type Work @default.
- W2950250770 sameAs 2950250770 @default.
- W2950250770 citedByCount "12" @default.
- W2950250770 countsByYear W29502507702020 @default.
- W2950250770 countsByYear W29502507702021 @default.
- W2950250770 countsByYear W29502507702022 @default.
- W2950250770 countsByYear W29502507702023 @default.
- W2950250770 crossrefType "journal-article" @default.
- W2950250770 hasAuthorship W2950250770A5057736752 @default.