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• W2950261377 abstract "CRISPR-based single-cell pooled screens that use linked barcodes suffer from lost sensitivity due to lentiviral template switching. The barcode-free CROP-seq design circumvents this problem. Several groups recently coupled CRISPR perturbations and single-cell RNA-seq for pooled genetic screens. We demonstrate that vector designs of these studies are susceptible to ∼50% swapping of guide RNA–barcode associations because of lentiviral template switching. We optimized a published alternative, CROP-seq, in which the guide RNA also serves as the barcode, and here confirm that this strategy performs robustly and doubled the rate at which guides are assigned to cells to 94%." @default.
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• W2950261377 date "2018-02-19" @default.
• W2950261377 modified "2023-10-18" @default.
• W2950261377 title "On the design of CRISPR-based single-cell molecular screens" @default.
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• W2950261377 doi "https://doi.org/10.1038/nmeth.4604" @default.
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