FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950271949> ?p ?o ?g. }

• W2950271949 abstract "Rising atmospheric oxygen (O2) levels provided a selective pressure for the evolution of O2-dependent micro-organisms that began with the autotrophic eukaryotes. Since these primordial times, the respiring mammalian cell has become entirely dependent on the constancy of electron flow with molecular O2 serving as the terminal electron acceptor in mitochondrial oxidative phosphorylation. Indeed, the ability to “sense” O2 and maintain homeostasis is considered one of the most important roles of the central nervous system (CNS) and likely represented a major driving force in the evolution of the human brain. Today, modern humans have evolved with an oversized brain committed to a continually active state and as a consequence, paradoxically vulnerable to failure if the O2 supply is interrupted. However, our pre-occupation with O2, the elixir of life, obscures the fact that it is a gas with a Janus Face, capable of sustaining life in physiologically controlled amounts yet paradoxically deadly to the CNS when in excess. A closer look at its quantum structure reveals precisely why; the triplet ground state diatomic O2 molecule is paramagnetic and exists in air as a free radical, constrained from reacting aggressively with the brain’s organic molecules due to its “spin restriction”, a thermodynamic quirk of evolutionary fate. By further exploring O2’s free radical “quantum quirkiness” including emergent quantum physiological phenomena, our understanding of precisely how the human brain senses O2 deprivation (hypoxia) and the elaborate redox-signaling defense mechanisms that defend O2 homeostasis has the potential to offer unique insights into the pathophysiology and treatment of human brain disease." @default.
• W2950271949 created "2019-06-27" @default.
• W2950271949 creator A5034633200 @default.
• W2950271949 date "2018-10-17" @default.
• W2950271949 modified "2023-10-09" @default.
• W2950271949 title "RETRACTED ARTICLE: The quantum physiology of oxygen; from electrons to the evolution of redox signaling in the human brain" @default.
• W2950271949 cites W1545536250 @default.
• W2950271949 cites W1602845909 @default.
• W2950271949 cites W1634882007 @default.
• W2950271949 cites W1828441724 @default.
• W2950271949 cites W1841582342 @default.
• W2950271949 cites W1879184430 @default.
• W2950271949 cites W1966084915 @default.
• W2950271949 cites W1977058357 @default.
• W2950271949 cites W1980270634 @default.
• W2950271949 cites W1986711229 @default.
• W2950271949 cites W1989812133 @default.
• W2950271949 cites W1993803019 @default.
• W2950271949 cites W1994237759 @default.
• W2950271949 cites W2003382100 @default.
• W2950271949 cites W2009771084 @default.
• W2950271949 cites W2011230760 @default.
• W2950271949 cites W2013427102 @default.
• W2950271949 cites W2016934775 @default.
• W2950271949 cites W2017629445 @default.
• W2950271949 cites W2019663885 @default.
• W2950271949 cites W2020498032 @default.
• W2950271949 cites W2025924576 @default.
• W2950271949 cites W2032833833 @default.
• W2950271949 cites W2032940945 @default.
• W2950271949 cites W2033240573 @default.
• W2950271949 cites W2033357754 @default.
• W2950271949 cites W2037156065 @default.
• W2950271949 cites W2042105409 @default.
• W2950271949 cites W2042422091 @default.
• W2950271949 cites W2045678449 @default.
• W2950271949 cites W2051847425 @default.
• W2950271949 cites W2053209359 @default.
• W2950271949 cites W2061242359 @default.
• W2950271949 cites W2071496657 @default.
• W2950271949 cites W2073743860 @default.
• W2950271949 cites W2083252150 @default.
• W2950271949 cites W2085813069 @default.
• W2950271949 cites W2090639755 @default.
• W2950271949 cites W2091340900 @default.
• W2950271949 cites W2101837144 @default.
• W2950271949 cites W2106620506 @default.
• W2950271949 cites W2108921478 @default.
• W2950271949 cites W2109802670 @default.
• W2950271949 cites W2110113233 @default.
• W2950271949 cites W2111496468 @default.
• W2950271949 cites W2111760435 @default.
• W2950271949 cites W2120924986 @default.
• W2950271949 cites W2123162584 @default.
• W2950271949 cites W2125022423 @default.
• W2950271949 cites W2125863862 @default.
• W2950271949 cites W2126527512 @default.
• W2950271949 cites W2131278302 @default.
• W2950271949 cites W2132826785 @default.
• W2950271949 cites W2141708266 @default.
• W2950271949 cites W2144918294 @default.
• W2950271949 cites W2147154204 @default.
• W2950271949 cites W2147270524 @default.
• W2950271949 cites W2153355885 @default.
• W2950271949 cites W2153628939 @default.
• W2950271949 cites W2153664306 @default.
• W2950271949 cites W2157358457 @default.
• W2950271949 cites W2161877652 @default.
• W2950271949 cites W2163234334 @default.
• W2950271949 cites W2165303310 @default.
• W2950271949 cites W2166566757 @default.
• W2950271949 cites W2166865790 @default.
• W2950271949 cites W2167674778 @default.
• W2950271949 cites W2170552040 @default.
• W2950271949 cites W2171317199 @default.
• W2950271949 cites W2171516150 @default.
• W2950271949 cites W2266097020 @default.
• W2950271949 cites W2270952372 @default.
• W2950271949 cites W2321579509 @default.
• W2950271949 cites W2377862130 @default.
• W2950271949 cites W2417221237 @default.
• W2950271949 cites W2419267597 @default.
• W2950271949 cites W2489932273 @default.
• W2950271949 cites W2490933368 @default.
• W2950271949 cites W2491973535 @default.
• W2950271949 cites W2507491151 @default.
• W2950271949 cites W2508496166 @default.
• W2950271949 cites W2508661753 @default.
• W2950271949 cites W2552029688 @default.
• W2950271949 cites W2553395030 @default.
• W2950271949 cites W2565566049 @default.
• W2950271949 cites W2566002710 @default.
• W2950271949 cites W2571918371 @default.
• W2950271949 cites W2581259096 @default.
• W2950271949 cites W2583149454 @default.
• W2950271949 cites W2621074013 @default.
• W2950271949 cites W2623854426 @default.
• W2950271949 cites W2626708394 @default.
• W2950271949 cites W2765151170 @default.
• W2950271949 cites W2765703742 @default.

• next