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• W2950275310 endingPage "3073" @default.
• W2950275310 startingPage "3073" @default.
• W2950275310 abstract "Bordetella pertussis is a Gram-negative strictly human pathogen of the respiratory tract and the etiological agent of whooping cough (pertussis). Previously, we have shown that RNA chaperone Hfq is required for virulence of B. pertussis. Furthermore, microarray analysis revealed that a large number of genes are affected by the lack of Hfq. This study represents the first attempt to characterize the Hfq regulon in bacterial pathogen using an integrative omics approach. Gene expression profiles were analyzed by RNA-seq and protein amounts in cell-associated and cell-free fractions were determined by LC-MS/MS technique. Comparative analysis of transcriptomic and proteomic data revealed solid correlation (r2 = 0.4) considering the role of Hfq in post-transcriptional control of gene expression. Importantly, our study confirms and further enlightens the role of Hfq in pathogenicity of B. pertussis as it shows that Δhfq strain displays strongly impaired secretion of substrates of Type III secretion system (T3SS) and substantially reduced resistance to serum killing. On the other hand, significantly increased production of proteins implicated in transport of important metabolites and essential nutrients observed in the mutant seems to compensate for the physiological defect introduced by the deletion of the hfq gene." @default.
• W2950275310 created "2019-06-27" @default.
• W2950275310 creator A5003442431 @default.
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• W2950275310 creator A5086092573 @default.
• W2950275310 date "2019-06-24" @default.
• W2950275310 modified "2023-10-16" @default.
• W2950275310 title "Comparative Integrated Omics Analysis of the Hfq Regulon in Bordetella pertussis" @default.
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• W2950275310 doi "https://doi.org/10.3390/ijms20123073" @default.
• W2950275310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6627887" @default.
• W2950275310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31238496" @default.
• W2950275310 hasPublicationYear "2019" @default.
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