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- W2950275890 abstract "Early characterization of new drug substances intended for oral application includes not only physicochemical properties and stability but also the ability of the substance to permeate through the intestinal mucosa. In this work, a rapid screening method, surface activity profiling (SAP), is proposed as an alternative to animal studies and screening in cell cultures. Measurements are made with a multichannel tensiometer and require only 50 µl of stock solution for the complete permeability analysis. Correlation of SAP results with human absorption was demonstrated for marketed drugs and with absorption in rats for development compounds of Boehringer Ingelheim. Cross-laboratory results for marketed drugs showed excellent agreement. For early stage investigations of lead compounds, where only small amounts of the compound are available, the SAP method appears to be an effective and fast tool to accurately predict fa, provided the compound is amphiphilic." @default.
- W2950275890 created "2019-06-27" @default.
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- W2950275890 date "2019-09-01" @default.
- W2950275890 modified "2023-09-26" @default.
- W2950275890 title "Surface Activity Profiling (SAP): A potential means of predicting intestinal membrane permeability" @default.
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- W2950275890 doi "https://doi.org/10.1016/j.ejpb.2019.06.024" @default.
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