Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950287992> ?p ?o ?g. }
- W2950287992 endingPage "76" @default.
- W2950287992 startingPage "64" @default.
- W2950287992 abstract "Few animal studies focus on consequences of nicotine postnatal exposure, particularly through lactation. We have recently shown that forced nicotine drinking elevates maternal care, paradoxically provoking arousal and stress in pups. Present work aimed to evaluate the specific contribution of altered maternal cares, compared to the sequelae merely due to nicotine effects. Two groups were compared to water-drinking control dams: (i) free-choice dams (H2O + NIC group) drinking from two bottles, containing either nicotine or water; (ii) forced dams (NIC + NIC group) drinking from two bottles, both containing nicotine. We previously demonstrated that nicotine was indeed transferred to the lactating offspring. Regarding behavioural consequences at adolescence, both H2O + NIC and NIC + NIC rats were slower than controls in discovering a novel over a familiar compartment, whilst only NIC + NIC rats exhibited reduced risk-related avoidance and assessment behaviour. Brain analyses at adulthood suggest that, in prefrontal cortex, nicotine per se reduced serotonin, while the maternal overcare reduced CHRN-B2 gene-expression. As a whole, unescapable nicotine-enhanced maternal care could have an impact on the offspring arousal by acting on prefrontal CHRN-B2 gene-expression. When present results are translated to consequences of non-voluntary exposure in humans, we propose that children receiving altered attentions by a smoking caregiver might undergo a neuro-behavioural development biased towards emotional shyness." @default.
- W2950287992 created "2019-06-27" @default.
- W2950287992 creator A5003828082 @default.
- W2950287992 creator A5007324451 @default.
- W2950287992 creator A5023633160 @default.
- W2950287992 creator A5030635348 @default.
- W2950287992 creator A5036610942 @default.
- W2950287992 creator A5065222117 @default.
- W2950287992 creator A5068021274 @default.
- W2950287992 creator A5068583314 @default.
- W2950287992 creator A5074270662 @default.
- W2950287992 creator A5080524725 @default.
- W2950287992 date "2019-08-01" @default.
- W2950287992 modified "2023-10-18" @default.
- W2950287992 title "Reduced adolescent risk-assessment and lower nicotinic beta-2 expression in rats exposed to nicotine through lactation by forcedly drinking dams" @default.
- W2950287992 cites W1876238371 @default.
- W2950287992 cites W1977915489 @default.
- W2950287992 cites W1978071150 @default.
- W2950287992 cites W1989808760 @default.
- W2950287992 cites W1994298252 @default.
- W2950287992 cites W1995227171 @default.
- W2950287992 cites W1998128125 @default.
- W2950287992 cites W2006875263 @default.
- W2950287992 cites W2008382653 @default.
- W2950287992 cites W2009480086 @default.
- W2950287992 cites W2012823048 @default.
- W2950287992 cites W2013977248 @default.
- W2950287992 cites W2019864496 @default.
- W2950287992 cites W2023379737 @default.
- W2950287992 cites W2027336097 @default.
- W2950287992 cites W2029111326 @default.
- W2950287992 cites W2031468801 @default.
- W2950287992 cites W2033177616 @default.
- W2950287992 cites W2033658160 @default.
- W2950287992 cites W2039021314 @default.
- W2950287992 cites W2040932099 @default.
- W2950287992 cites W2042897185 @default.
- W2950287992 cites W2042902112 @default.
- W2950287992 cites W2048025784 @default.
- W2950287992 cites W2051695751 @default.
- W2950287992 cites W2053225292 @default.
- W2950287992 cites W2055686502 @default.
- W2950287992 cites W2060192636 @default.
- W2950287992 cites W2061813552 @default.
- W2950287992 cites W2066371075 @default.
- W2950287992 cites W2071489843 @default.
- W2950287992 cites W2072987235 @default.
- W2950287992 cites W2093843951 @default.
- W2950287992 cites W2102430753 @default.
- W2950287992 cites W2104890863 @default.
- W2950287992 cites W2117939256 @default.
- W2950287992 cites W2124994926 @default.
- W2950287992 cites W2129925362 @default.
- W2950287992 cites W2134294855 @default.
- W2950287992 cites W2138074420 @default.
- W2950287992 cites W2139707202 @default.
- W2950287992 cites W2142621488 @default.
- W2950287992 cites W2143436666 @default.
- W2950287992 cites W2143677714 @default.
- W2950287992 cites W2147767615 @default.
- W2950287992 cites W2151744546 @default.
- W2950287992 cites W2164537043 @default.
- W2950287992 cites W2178837340 @default.
- W2950287992 cites W2263002125 @default.
- W2950287992 cites W2288701263 @default.
- W2950287992 cites W2314030043 @default.
- W2950287992 cites W2329921611 @default.
- W2950287992 cites W2332330514 @default.
- W2950287992 cites W2397045879 @default.
- W2950287992 cites W2530841469 @default.
- W2950287992 cites W2533131999 @default.
- W2950287992 cites W2588712075 @default.
- W2950287992 cites W2590266639 @default.
- W2950287992 cites W2591590721 @default.
- W2950287992 cites W2740573049 @default.
- W2950287992 cites W2743110535 @default.
- W2950287992 cites W2757528785 @default.
- W2950287992 cites W2800560903 @default.
- W2950287992 cites W2883696538 @default.
- W2950287992 cites W2884323663 @default.
- W2950287992 cites W4248526027 @default.
- W2950287992 cites W938393872 @default.
- W2950287992 cites W977330045 @default.
- W2950287992 doi "https://doi.org/10.1016/j.neuroscience.2019.06.014" @default.
- W2950287992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31228592" @default.
- W2950287992 hasPublicationYear "2019" @default.
- W2950287992 type Work @default.
- W2950287992 sameAs 2950287992 @default.
- W2950287992 citedByCount "6" @default.
- W2950287992 countsByYear W29502879922019 @default.
- W2950287992 countsByYear W29502879922021 @default.
- W2950287992 countsByYear W29502879922022 @default.
- W2950287992 crossrefType "journal-article" @default.
- W2950287992 hasAuthorship W2950287992A5003828082 @default.
- W2950287992 hasAuthorship W2950287992A5007324451 @default.
- W2950287992 hasAuthorship W2950287992A5023633160 @default.
- W2950287992 hasAuthorship W2950287992A5030635348 @default.
- W2950287992 hasAuthorship W2950287992A5036610942 @default.