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• W2950292270 endingPage "76" @default.
• W2950292270 startingPage "60" @default.
• W2950292270 abstract "This minireview describes the state-of-the-art of available (Q)SARs/expert systems for skin sensitization and evaluates their utility for potential regulatory use. It is one of a series of minireviews in this journal and is based on an in-depth review performed by the European Chemicals Bureau (ECB) of the European Commission's Joint Research Centre (JRC) in support of the development of technical guidance for the implementation of the Registration, Evaluation, and Authorization of CHemicals (REACH) legislation. Most existing models fall into one of two main categories: either they are local in nature, usually specific to a chemical class or reaction chemical mechanism or else they are global in form, derived empirically using statistical methods. Some global QSARs have been recently characterized in accordance with the OECD validation principles and shown to be of limited use for regulatory applications. These have been evaluated in more detail elsewhere. Expert systems capable of predicting skin sensitization are discussed briefly. The strong mechanistic understanding of skin sensitization has facilitated the development of relative alkylation index (RAI) models. The RAI approach, relying on reactivity and hydrophobicity as the key parameters, actually appears to be the most promising means of deriving robust and mechanistically interpretable models which can be applied in a regulatory context. These are now referred to as Quantitative Mechanistic Models (QMM). Whilst hydrophobicity is conveniently modelled using log P, reactivity is often not easily determined from chemical structure. Initiatives are in progress to generate the necessary reactivity data for reactions relevant to skin sensitization but more resources are still required. A strategy of how information from using the RAI approach can be used in the evaluation of skin sensitization potential is described. This is the subject of on-going and future work." @default.
• W2950292270 created "2019-06-27" @default.
• W2950292270 creator A5011168879 @default.
• W2950292270 creator A5012966223 @default.
• W2950292270 creator A5034652034 @default.
• W2950292270 creator A5070602119 @default.
• W2950292270 date "2008-01-01" @default.
• W2950292270 modified "2023-10-11" @default.
• W2950292270 title "A Minireview of Available Skin Sensitization (Q)SARs/Expert Systems" @default.
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