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- W2950294163 abstract "Abstract Rapid advances in sequencing technologies are producing genomic data on an unprecedented scale. The first, and often one of the most time consuming, step of genomic data analysis is sequence alignment, where sequenced reads must be aligned to a reference genome. Several years of research on alignment algorithms has led to the development of several state-of-the-art sequence aligners that can map tens of thousands of reads per second. In this work, we answer the question “How do sequence aligners utilize modern processors?” We examine four state-of-the-art aligners running on an Intel processor and identify that all aligners leave the processor substantially underutilized. We perform an in-depth microarchitectural analysis to explore the interaction between aligner software and processor hardware. We identify bottlenecks that lead to processor underutilization and discuss the implications of our analysis on next-generation sequence aligner design." @default.
- W2950294163 created "2019-06-27" @default.
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- W2950294163 date "2018-01-30" @default.
- W2950294163 modified "2023-10-02" @default.
- W2950294163 title "Sequence Alignment Through the Looking Glass" @default.
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- W2950294163 doi "https://doi.org/10.1101/256859" @default.
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