FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950312622> ?p ?o ?g. }

• W2950312622 endingPage "3078" @default.
• W2950312622 startingPage "3078" @default.
• W2950312622 abstract "Raman spectroscopy, which is a suitable tool to elucidate the structural properties of intrinsically disordered proteins, was applied to investigate the changes in both the structure and the conformational heterogeneity of the DNA-binding domain (DBD) belonging to the intrinsically disordered protein p53 upon its binding to Azurin, an electron-transfer anticancer protein from Pseudomonas aeruginosa. The Raman spectra of the DBD and Azurin, isolated in solution or forming a complex, were analyzed by a combined analysis based on peak inspection, band convolution, and principal component analysis (PCA). In particular, our attention was focused on the Raman peaks of Tyrosine and Tryptophan residues, which are diagnostic markers of protein side chain environment, and on the Amide I band, of which the deconvolution allows us to extract information about α-helix, β-sheet, and random coil contents. The results show an increase of the secondary structure content of DBD concomitantly with a decrease of its conformational heterogeneity upon its binding to Azurin. These findings suggest an Azurin-induced conformational change of DBD structure with possible implications for p53 functionality." @default.
• W2950312622 created "2019-06-27" @default.
• W2950312622 creator A5005527542 @default.
• W2950312622 creator A5036589086 @default.
• W2950312622 creator A5039099214 @default.
• W2950312622 date "2019-06-24" @default.
• W2950312622 modified "2023-09-26" @default.
• W2950312622 title "Raman Evidence of p53-DBD Disorder Decrease upon Interaction with the Anticancer Protein Azurin" @default.
• W2950312622 cites W1505488619 @default.
• W2950312622 cites W1526451670 @default.
• W2950312622 cites W1772256520 @default.
• W2950312622 cites W1826491522 @default.
• W2950312622 cites W1890766043 @default.
• W2950312622 cites W1934853983 @default.
• W2950312622 cites W1968888329 @default.
• W2950312622 cites W1976946487 @default.
• W2950312622 cites W1987517037 @default.
• W2950312622 cites W1999989283 @default.
• W2950312622 cites W2002685197 @default.
• W2950312622 cites W2002782860 @default.
• W2950312622 cites W2006741691 @default.
• W2950312622 cites W2007879544 @default.
• W2950312622 cites W2008332643 @default.
• W2950312622 cites W2017182837 @default.
• W2950312622 cites W2018617249 @default.
• W2950312622 cites W2019577939 @default.
• W2950312622 cites W2023577360 @default.
• W2950312622 cites W2028181978 @default.
• W2950312622 cites W2028374237 @default.
• W2950312622 cites W2030783330 @default.
• W2950312622 cites W2031683089 @default.
• W2950312622 cites W2033383787 @default.
• W2950312622 cites W2038716667 @default.
• W2950312622 cites W2051355276 @default.
• W2950312622 cites W2056722520 @default.
• W2950312622 cites W2061271983 @default.
• W2950312622 cites W2067680762 @default.
• W2950312622 cites W2069339663 @default.
• W2950312622 cites W2081184407 @default.
• W2950312622 cites W2092913037 @default.
• W2950312622 cites W2096276671 @default.
• W2950312622 cites W2109998141 @default.
• W2950312622 cites W2130384960 @default.
• W2950312622 cites W2149472608 @default.
• W2950312622 cites W2151143141 @default.
• W2950312622 cites W2165242628 @default.
• W2950312622 cites W2276851470 @default.
• W2950312622 cites W2292301738 @default.
• W2950312622 cites W2322112264 @default.
• W2950312622 cites W2333815586 @default.
• W2950312622 cites W2474781036 @default.
• W2950312622 cites W2581729326 @default.
• W2950312622 cites W2585452191 @default.
• W2950312622 doi "https://doi.org/10.3390/ijms20123078" @default.
• W2950312622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6627904" @default.
• W2950312622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31238511" @default.
• W2950312622 hasPublicationYear "2019" @default.
• W2950312622 type Work @default.
• W2950312622 sameAs 2950312622 @default.
• W2950312622 citedByCount "12" @default.
• W2950312622 countsByYear W29503126222020 @default.
• W2950312622 countsByYear W29503126222021 @default.
• W2950312622 countsByYear W29503126222022 @default.
• W2950312622 crossrefType "journal-article" @default.
• W2950312622 hasAuthorship W2950312622A5005527542 @default.
• W2950312622 hasAuthorship W2950312622A5036589086 @default.
• W2950312622 hasAuthorship W2950312622A5039099214 @default.
• W2950312622 hasBestOaLocation W29503126221 @default.
• W2950312622 hasConcept C120665830 @default.
• W2950312622 hasConcept C121332964 @default.
• W2950312622 hasConcept C123669783 @default.
• W2950312622 hasConcept C12554922 @default.
• W2950312622 hasConcept C185592680 @default.
• W2950312622 hasConcept C18903297 @default.
• W2950312622 hasConcept C2776706248 @default.
• W2950312622 hasConcept C2777339483 @default.
• W2950312622 hasConcept C2778530040 @default.
• W2950312622 hasConcept C2778574204 @default.
• W2950312622 hasConcept C2779965526 @default.
• W2950312622 hasConcept C34349673 @default.
• W2950312622 hasConcept C40003534 @default.
• W2950312622 hasConcept C47701112 @default.
• W2950312622 hasConcept C515207424 @default.
• W2950312622 hasConcept C55493867 @default.
• W2950312622 hasConcept C62614982 @default.
• W2950312622 hasConcept C75473681 @default.
• W2950312622 hasConcept C8010536 @default.
• W2950312622 hasConcept C86803240 @default.
• W2950312622 hasConceptScore W2950312622C120665830 @default.
• W2950312622 hasConceptScore W2950312622C121332964 @default.
• W2950312622 hasConceptScore W2950312622C123669783 @default.
• W2950312622 hasConceptScore W2950312622C12554922 @default.
• W2950312622 hasConceptScore W2950312622C185592680 @default.
• W2950312622 hasConceptScore W2950312622C18903297 @default.
• W2950312622 hasConceptScore W2950312622C2776706248 @default.
• W2950312622 hasConceptScore W2950312622C2777339483 @default.
• W2950312622 hasConceptScore W2950312622C2778530040 @default.
• W2950312622 hasConceptScore W2950312622C2778574204 @default.

• next