Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950316767> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2950316767 abstract "Phenylglycinol-derived oxazolopiperidone lac- tams are exceptionally versatile building blocks for the enantioselective construction of structurally diverse pi- peridine-containing natural products and bioactive com- pounds. These lactams are readily available in both enantiomeric series by cyclocondensation of the chiral amino alcohol with a d-oxo acid derivative and allow the substituents to be introduced at the different ring positions in a regio- and stereocontrolled manner, pro- viding access to enantiopure polysubstituted piperidines bearing virtually any type of substitution pattern, and also quinolizidines, indolizidines, perhydroquinolines, hydroisoquinolines, as well as complex indole alkaloids. Of particular interest are cyclocondensation reactions with racemic or prochiral d-oxo (di)acid derivatives in processes involving dynamic kinetic resolution and/or differentiation of enantiotopic or diastereotopic ester groups, as they directly lead to lactams that already in- corporate the carbon substituents on the heterocyclic ring. The use of (S)-3,4-dimethoxyphenylalaninol or (S)- tryptophanol in the above cyclocondensation reactions expands the potential and the scope of the methodolo- gy, providing a straightforward route to enantiopure benzo(a)- and indoloAa)quinolizidines." @default.
- W2950316767 created "2019-06-27" @default.
- W2950316767 creator A5014507499 @default.
- W2950316767 creator A5017299571 @default.
- W2950316767 creator A5090239201 @default.
- W2950316767 date "2007-02-06" @default.
- W2950316767 modified "2023-09-26" @default.
- W2950316767 title "Chiral Oxazolopiperidone Lactams: Versatile Intermediates for the Enantioselective Synthesis of Piperidine-Containing Natural Products" @default.
- W2950316767 cites W2137781848 @default.
- W2950316767 doi "https://doi.org/10.1002/chin.200706243" @default.
- W2950316767 hasPublicationYear "2007" @default.
- W2950316767 type Work @default.
- W2950316767 sameAs 2950316767 @default.
- W2950316767 citedByCount "0" @default.
- W2950316767 crossrefType "journal-article" @default.
- W2950316767 hasAuthorship W2950316767A5014507499 @default.
- W2950316767 hasAuthorship W2950316767A5017299571 @default.
- W2950316767 hasAuthorship W2950316767A5090239201 @default.
- W2950316767 hasConcept C146686406 @default.
- W2950316767 hasConcept C161790260 @default.
- W2950316767 hasConcept C178790620 @default.
- W2950316767 hasConcept C185592680 @default.
- W2950316767 hasConcept C192527728 @default.
- W2950316767 hasConcept C21951064 @default.
- W2950316767 hasConcept C2780378348 @default.
- W2950316767 hasConcept C2781462491 @default.
- W2950316767 hasConcept C28173026 @default.
- W2950316767 hasConcept C486523 @default.
- W2950316767 hasConcept C71240020 @default.
- W2950316767 hasConcept C93237805 @default.
- W2950316767 hasConceptScore W2950316767C146686406 @default.
- W2950316767 hasConceptScore W2950316767C161790260 @default.
- W2950316767 hasConceptScore W2950316767C178790620 @default.
- W2950316767 hasConceptScore W2950316767C185592680 @default.
- W2950316767 hasConceptScore W2950316767C192527728 @default.
- W2950316767 hasConceptScore W2950316767C21951064 @default.
- W2950316767 hasConceptScore W2950316767C2780378348 @default.
- W2950316767 hasConceptScore W2950316767C2781462491 @default.
- W2950316767 hasConceptScore W2950316767C28173026 @default.
- W2950316767 hasConceptScore W2950316767C486523 @default.
- W2950316767 hasConceptScore W2950316767C71240020 @default.
- W2950316767 hasConceptScore W2950316767C93237805 @default.
- W2950316767 hasLocation W29503167671 @default.
- W2950316767 hasOpenAccess W2950316767 @default.
- W2950316767 hasPrimaryLocation W29503167671 @default.
- W2950316767 hasRelatedWork W1992112711 @default.
- W2950316767 hasRelatedWork W2080443101 @default.
- W2950316767 hasRelatedWork W2094871349 @default.
- W2950316767 hasRelatedWork W2153014742 @default.
- W2950316767 hasRelatedWork W2165632457 @default.
- W2950316767 hasRelatedWork W2313942307 @default.
- W2950316767 hasRelatedWork W2399541805 @default.
- W2950316767 hasRelatedWork W2554893025 @default.
- W2950316767 hasRelatedWork W2949294999 @default.
- W2950316767 hasRelatedWork W2951313446 @default.
- W2950316767 isParatext "false" @default.
- W2950316767 isRetracted "false" @default.
- W2950316767 magId "2950316767" @default.
- W2950316767 workType "article" @default.