Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950319457> ?p ?o ?g. }
- W2950319457 endingPage "65" @default.
- W2950319457 startingPage "52" @default.
- W2950319457 abstract "Hematopoietic cell lineages support organismal needs by responding to positional and systemic signals that balance proliferative and differentiation events. Drosophila provides an excellent genetic model to dissect these signals, where the activity of cues in the hemolymph or substrate can be traced to determination and differentiation events of well characterized hemocyte types. Plasmatocytes in third instar larvae increase in number in response to infection and in anticipation of metamorphosis. Here we characterize hemocyte clustering, proliferation and transdifferentiation on the heart or dorsal vessel. Hemocytes accumulate on the inner foldings of the heart basement membrane, where they move with heart contraction, and are in proximity to the heart ostia and pericardial nephrocytes. The numbers of hemocytes vary, but increase transiently before pupariation, and decrease by 4 h before pupa formation. During their accumulation at the heart, plasmatocytes can proliferate and can transdifferentiate into crystal cells. Serrate expressing cells as well as lamellocyte-like, Atilla expressing ensheathing cells are associated with some, but not all hemocyte clusters. Hemocyte aggregation is enhanced by the presence of a heart specific Collagen, Pericardin, but not the associated pericardial cells. The varied and transient number of hemocytes in the pericardial compartment suggests that this is not a hematopoietic hub, but a niche supporting differentiation and rapid dispersal in response to systemic signals." @default.
- W2950319457 created "2019-06-27" @default.
- W2950319457 creator A5036089365 @default.
- W2950319457 creator A5054717532 @default.
- W2950319457 creator A5077317125 @default.
- W2950319457 creator A5087569754 @default.
- W2950319457 date "2019-10-01" @default.
- W2950319457 modified "2023-10-04" @default.
- W2950319457 title "Pericardin, a Drosophila collagen, facilitates accumulation of hemocytes at the heart" @default.
- W2950319457 cites W1564415256 @default.
- W2950319457 cites W1751935826 @default.
- W2950319457 cites W1801631812 @default.
- W2950319457 cites W1863307599 @default.
- W2950319457 cites W1964226379 @default.
- W2950319457 cites W1967042670 @default.
- W2950319457 cites W1972127223 @default.
- W2950319457 cites W1973394316 @default.
- W2950319457 cites W1976257234 @default.
- W2950319457 cites W1977784231 @default.
- W2950319457 cites W1977992867 @default.
- W2950319457 cites W1982100452 @default.
- W2950319457 cites W1982650114 @default.
- W2950319457 cites W1984980675 @default.
- W2950319457 cites W1988949130 @default.
- W2950319457 cites W1989599722 @default.
- W2950319457 cites W1994648165 @default.
- W2950319457 cites W1994928799 @default.
- W2950319457 cites W1999644185 @default.
- W2950319457 cites W2003350388 @default.
- W2950319457 cites W2006239474 @default.
- W2950319457 cites W2009594373 @default.
- W2950319457 cites W2011819366 @default.
- W2950319457 cites W2013333878 @default.
- W2950319457 cites W2017198154 @default.
- W2950319457 cites W2022001110 @default.
- W2950319457 cites W2022482942 @default.
- W2950319457 cites W2035478311 @default.
- W2950319457 cites W2040236732 @default.
- W2950319457 cites W2044754775 @default.
- W2950319457 cites W2045032544 @default.
- W2950319457 cites W2047432389 @default.
- W2950319457 cites W2047608367 @default.
- W2950319457 cites W2047653899 @default.
- W2950319457 cites W2055083701 @default.
- W2950319457 cites W2055116456 @default.
- W2950319457 cites W2055204695 @default.
- W2950319457 cites W2060077669 @default.
- W2950319457 cites W2062971078 @default.
- W2950319457 cites W2064292608 @default.
- W2950319457 cites W2073938143 @default.
- W2950319457 cites W2077533241 @default.
- W2950319457 cites W2077885629 @default.
- W2950319457 cites W2080656460 @default.
- W2950319457 cites W2082644318 @default.
- W2950319457 cites W2093224184 @default.
- W2950319457 cites W2099540110 @default.
- W2950319457 cites W2114340303 @default.
- W2950319457 cites W2116805218 @default.
- W2950319457 cites W2125445451 @default.
- W2950319457 cites W2129736385 @default.
- W2950319457 cites W2131561091 @default.
- W2950319457 cites W2137196972 @default.
- W2950319457 cites W2141932361 @default.
- W2950319457 cites W2147628979 @default.
- W2950319457 cites W2147921697 @default.
- W2950319457 cites W2150015205 @default.
- W2950319457 cites W2156852003 @default.
- W2950319457 cites W2159601147 @default.
- W2950319457 cites W2221864122 @default.
- W2950319457 cites W2298057030 @default.
- W2950319457 cites W2314725040 @default.
- W2950319457 cites W2345067109 @default.
- W2950319457 cites W2470374328 @default.
- W2950319457 cites W2485159600 @default.
- W2950319457 cites W2522322489 @default.
- W2950319457 cites W2610164166 @default.
- W2950319457 cites W2741708810 @default.
- W2950319457 cites W2790051625 @default.
- W2950319457 cites W2888899565 @default.
- W2950319457 cites W2912523138 @default.
- W2950319457 doi "https://doi.org/10.1016/j.ydbio.2019.06.006" @default.
- W2950319457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31228417" @default.
- W2950319457 hasPublicationYear "2019" @default.
- W2950319457 type Work @default.
- W2950319457 sameAs 2950319457 @default.
- W2950319457 citedByCount "21" @default.
- W2950319457 countsByYear W29503194572020 @default.
- W2950319457 countsByYear W29503194572021 @default.
- W2950319457 countsByYear W29503194572022 @default.
- W2950319457 countsByYear W29503194572023 @default.
- W2950319457 crossrefType "journal-article" @default.
- W2950319457 hasAuthorship W2950319457A5036089365 @default.
- W2950319457 hasAuthorship W2950319457A5054717532 @default.
- W2950319457 hasAuthorship W2950319457A5077317125 @default.
- W2950319457 hasAuthorship W2950319457A5087569754 @default.
- W2950319457 hasBestOaLocation W29503194571 @default.
- W2950319457 hasConcept C100068826 @default.
- W2950319457 hasConcept C104317684 @default.