Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950326516> ?p ?o ?g. }
- W2950326516 abstract "Exposure to perfluoroalkyl substances (PFAS), synthetic and persistent chemicals used in commercial and industrial processes, are associated with cardiometabolic dysfunction and related risk factors including reduced birth weight, excess adiposity, and dyslipidemia. Identifying the metabolic changes induced by PFAS exposure could enhance our understanding of biological pathways underlying PFAS toxicity.To identify metabolic alterations associated with serum concentrations of four PFAS in children using a metabolome-wide association study.We performed untargeted metabolomic profiling by liquid chromatography with ultra-high-resolution mass spectrometry, and separately quantified serum concentrations of perfluorooctanoic acid, perfluorooctanesulfonic acid, perfluorononanoic acid, and perfluorohexanesulfonic acid (PFHxS) for 114 8-year old children from Cincinnati, OH. We evaluated associations between each serum PFAS concentration and 16,097 metabolic features using linear regression adjusted for child age, sex, and race with a false discovery rate < 20%. We annotated PFAS-associated metabolites and conducted pathway enrichment analyses.Serum PFAS concentrations were associated with metabolic features annotated primarily as lipids and dietary factors. Biological pathways associated with all four PFAS included arginine, proline, aspartate, asparagine, and butanoate metabolism.In this cross-sectional study, childhood serum PFAS concentrations were correlated with metabolic pathways related to energy production and catabolism. Future studies should determine whether these pathways mediate associations between PFAS exposure and childhood cardiometabolic health." @default.
- W2950326516 created "2019-06-27" @default.
- W2950326516 creator A5013602281 @default.
- W2950326516 creator A5035904189 @default.
- W2950326516 creator A5055543813 @default.
- W2950326516 creator A5063846847 @default.
- W2950326516 creator A5070562722 @default.
- W2950326516 creator A5074562026 @default.
- W2950326516 creator A5076717906 @default.
- W2950326516 creator A5077730739 @default.
- W2950326516 creator A5079448339 @default.
- W2950326516 creator A5080164344 @default.
- W2950326516 date "2019-06-21" @default.
- W2950326516 modified "2023-10-01" @default.
- W2950326516 title "Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study" @default.
- W2950326516 cites W1484747638 @default.
- W2950326516 cites W1537044725 @default.
- W2950326516 cites W1611854178 @default.
- W2950326516 cites W1623684340 @default.
- W2950326516 cites W1695091605 @default.
- W2950326516 cites W1949944365 @default.
- W2950326516 cites W1969835924 @default.
- W2950326516 cites W1972550453 @default.
- W2950326516 cites W1975902105 @default.
- W2950326516 cites W1983925726 @default.
- W2950326516 cites W1984648008 @default.
- W2950326516 cites W1987638499 @default.
- W2950326516 cites W1990067807 @default.
- W2950326516 cites W1993650845 @default.
- W2950326516 cites W1996815439 @default.
- W2950326516 cites W2009453329 @default.
- W2950326516 cites W2012660994 @default.
- W2950326516 cites W2014992740 @default.
- W2950326516 cites W2019544391 @default.
- W2950326516 cites W2025315910 @default.
- W2950326516 cites W2025944550 @default.
- W2950326516 cites W2032047739 @default.
- W2950326516 cites W2034508698 @default.
- W2950326516 cites W2051252027 @default.
- W2950326516 cites W2059663974 @default.
- W2950326516 cites W2086662317 @default.
- W2950326516 cites W2107228744 @default.
- W2950326516 cites W2107665951 @default.
- W2950326516 cites W2110256992 @default.
- W2950326516 cites W2112558380 @default.
- W2950326516 cites W2115294221 @default.
- W2950326516 cites W2129768504 @default.
- W2950326516 cites W2133554081 @default.
- W2950326516 cites W2136859480 @default.
- W2950326516 cites W2144166917 @default.
- W2950326516 cites W2154672956 @default.
- W2950326516 cites W2159482845 @default.
- W2950326516 cites W2232390271 @default.
- W2950326516 cites W2268479893 @default.
- W2950326516 cites W2303415821 @default.
- W2950326516 cites W2318476459 @default.
- W2950326516 cites W2335224112 @default.
- W2950326516 cites W2338627428 @default.
- W2950326516 cites W2462794150 @default.
- W2950326516 cites W2472566625 @default.
- W2950326516 cites W2480204771 @default.
- W2950326516 cites W2512299796 @default.
- W2950326516 cites W2518686384 @default.
- W2950326516 cites W2526986571 @default.
- W2950326516 cites W2553727184 @default.
- W2950326516 cites W2559588208 @default.
- W2950326516 cites W2561291010 @default.
- W2950326516 cites W2624588518 @default.
- W2950326516 cites W2666354105 @default.
- W2950326516 cites W2702911264 @default.
- W2950326516 cites W2756301349 @default.
- W2950326516 cites W2757087770 @default.
- W2950326516 cites W2760801784 @default.
- W2950326516 cites W2762019316 @default.
- W2950326516 cites W2767683865 @default.
- W2950326516 cites W2801839496 @default.
- W2950326516 cites W2891523709 @default.
- W2950326516 cites W2902865730 @default.
- W2950326516 cites W2918371302 @default.
- W2950326516 cites W4243002209 @default.
- W2950326516 cites W4294216483 @default.
- W2950326516 doi "https://doi.org/10.1007/s11306-019-1560-z" @default.
- W2950326516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7172933" @default.
- W2950326516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31227916" @default.
- W2950326516 hasPublicationYear "2019" @default.
- W2950326516 type Work @default.
- W2950326516 sameAs 2950326516 @default.
- W2950326516 citedByCount "43" @default.
- W2950326516 countsByYear W29503265162019 @default.
- W2950326516 countsByYear W29503265162020 @default.
- W2950326516 countsByYear W29503265162021 @default.
- W2950326516 countsByYear W29503265162022 @default.
- W2950326516 countsByYear W29503265162023 @default.
- W2950326516 crossrefType "journal-article" @default.
- W2950326516 hasAuthorship W2950326516A5013602281 @default.
- W2950326516 hasAuthorship W2950326516A5035904189 @default.
- W2950326516 hasAuthorship W2950326516A5055543813 @default.
- W2950326516 hasAuthorship W2950326516A5063846847 @default.
- W2950326516 hasAuthorship W2950326516A5070562722 @default.
- W2950326516 hasAuthorship W2950326516A5074562026 @default.