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- W2950334472 abstract "A series of substituted 2-polyfluoroalkyl and 2-nitrobenzylsulphanyl benzimidazoles was synthesized. The compounds were evaluated for their activity against four Mycobacterium strains; the activities were expressed as the minimum inhibitory concentration (MIC). The substances tested showed appreciable antimycobacterial activity, particularly 5,6-dichloro-2-nonafluorobutylbenzimidazole (2h), and 5-halogeno- (5a-c) and 4,6-dihalogeno- (5d and 5g) 2-(3,5-dinitrobenzylsulphanyl)benzimidazoles, whose MIC values for Mycobacterium kansasii and Mycobacterium avium exceeded that of isoniazide that was used as a reference compound. Relationships between structure and biological activity of the tested benzimidazole derivatives are discussed." @default.
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- W2950334472 date "2005-06-28" @default.
- W2950334472 modified "2023-09-26" @default.
- W2950334472 title "Synthesis and Antimycobacterial Activity of 2-Substituted Halogenobenzimidazoles." @default.
- W2950334472 cites W2153527675 @default.
- W2950334472 doi "https://doi.org/10.1002/chin.200526070" @default.
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