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- W2950339966 abstract "2-Benzyl- and 2-aryloxymethyl-3-amino-1-phenyl-pyrazolo[3,4-d]pyrimidine-4-ones 5a–f have been synthesized by reacting the corresponding arylacetylamino derivatives 3a–f with hydrazine hydrate. Thionation of compounds 5d–f by action of P2S5 in pyridine yielded 2-aryloxy-methyl-3-amino-1-pheny-lpyrazolo[3,4-d]pyrimidin-4-thions 6a–c. 2,5-Diphenyl-2,3-dihydro-1H-pyrazolo[5′,1′:4:5]pyrazolo[3,4-d]pyrimidine-8-one (8) was also obtained via reaction of ethyl-2-cinnamoylamino-1-phenyl-pyrazole-4-car-boxylate (7) with hydrazine hydrate. The prepared compounds were screened in vitro for their antimicrobial activity. Some of the tested compounds were found to be active at 100 μg/ml compared with reference compounds (Ampicillin and Trivid) as antibacterial agents and claforan as antifungal agent. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:530–534, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10187" @default.
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- W2950339966 date "2003-01-01" @default.
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- W2950339966 title "Design, synthesis, and antimicrobial activity of some new pyrazolo[3,4-d]pyrimidines" @default.
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- W2950339966 doi "https://doi.org/10.1002/hc.10187" @default.
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