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- W2950342703 abstract "Serotonin (5-hydroxytryptamine, 5-HT) elicits complex responses in the cardiovascular system comprising bradycardia or tachycardia, hypotension or hypertension, and vasodilatation or vasoconstriction. These responses involve central and/or peripheral interactions with 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5A, and 5-HT7 receptors, as well as by a tyramine-like action or unidentified mechanisms. Interestingly, the 5-HT6 receptor is not involved (neither centrally nor peripherally) in cardiovascular regulation. Nevertheless, further research is required to identify the specific mechanisms involved in some cardiovascular actions of 5-HT, for example (1) the capability of 5-HT to amplify the vasoconstrictor responses to adrenergic and nonadrenergic neurohumoral mediators and (2) the (patho)physiological relevance of the receptor-independent intracellular actions of 5-HT, which depend on the activity of the 5-HT transporter. The advent of some selective 5-HT receptor agonists and antagonists has made it possible to develop medications with therapeutic usefulness in the treatment of some cardiovascular pathologies, including hypertension, migraine, and heart failure." @default.
- W2950342703 created "2019-06-27" @default.
- W2950342703 creator A5026439229 @default.
- W2950342703 date "2019-01-01" @default.
- W2950342703 modified "2023-09-23" @default.
- W2950342703 title "The role of serotonin receptors in the control of cardiovascular function" @default.
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- W2950342703 doi "https://doi.org/10.1016/b978-0-12-813323-1.00014-1" @default.
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