Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950349721> ?p ?o ?g. }
- W2950349721 abstract "Abstract The interaction between metabolism and the immune system plays a central role in many cardiometabolic diseases. We integrated blood transcriptomic, metabolomic, and genomic profiles from two population-based cohorts, including a subset with 7-year follow-up sampling. We identified topologically robust gene networks enriched for diverse immune functions including cytotoxicity, viral response, B cell, platelet, neutrophil, and mast cell/basophil activity. These immune gene modules showed complex patterns of association with 158 circulating metabolites, including lipoprotein subclasses, lipids, fatty acids, amino acids, and CRP. Genome-wide scans for module expression quantitative trait loci (mQTLs) revealed five modules with mQTLs of both cis and trans effects. The strongest mQTL was in ARHGEF3 (rs1354034) and affected a module enriched for platelet function. Mast cell/basophil and neutrophil function modules maintained their metabolite associations during 7-year follow-up, while our strongest mQTL in ARHGEF3 also displayed clear temporal stability. This study provides a detailed map of natural variation at the blood immuno-metabolic interface and its genetic basis, and facilitates subsequent studies to explain inter-individual variation in cardiometabolic disease." @default.
- W2950349721 created "2019-06-27" @default.
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- W2950349721 date "2016-11-26" @default.
- W2950349721 modified "2023-10-14" @default.
- W2950349721 title "An interaction map of circulating metabolites, immune gene networks and their genetic regulation" @default.
- W2950349721 cites W1224709979 @default.
- W2950349721 cites W1499386671 @default.
- W2950349721 cites W1511974199 @default.
- W2950349721 cites W1551999069 @default.
- W2950349721 cites W1576016841 @default.
- W2950349721 cites W1576093064 @default.
- W2950349721 cites W1577362137 @default.
- W2950349721 cites W1596079370 @default.
- W2950349721 cites W1835396192 @default.
- W2950349721 cites W1895802579 @default.
- W2950349721 cites W1898659608 @default.
- W2950349721 cites W1966327575 @default.
- W2950349721 cites W1966977991 @default.
- W2950349721 cites W1968747399 @default.
- W2950349721 cites W1969353942 @default.
- W2950349721 cites W1974033269 @default.
- W2950349721 cites W1974039875 @default.
- W2950349721 cites W1974770153 @default.
- W2950349721 cites W1981416031 @default.
- W2950349721 cites W1984015997 @default.
- W2950349721 cites W1985725780 @default.
- W2950349721 cites W1990902267 @default.
- W2950349721 cites W1991186601 @default.
- W2950349721 cites W1992436001 @default.
- W2950349721 cites W1994766646 @default.
- W2950349721 cites W2013223495 @default.
- W2950349721 cites W2017784877 @default.
- W2950349721 cites W2026336857 @default.
- W2950349721 cites W2030739472 @default.
- W2950349721 cites W2036720248 @default.
- W2950349721 cites W2036891888 @default.
- W2950349721 cites W2037792151 @default.
- W2950349721 cites W2038963685 @default.
- W2950349721 cites W2039052668 @default.
- W2950349721 cites W2040691054 @default.
- W2950349721 cites W2041600084 @default.
- W2950349721 cites W2043793366 @default.
- W2950349721 cites W2046737719 @default.
- W2950349721 cites W2057198053 @default.
- W2950349721 cites W2068509302 @default.
- W2950349721 cites W2069310363 @default.
- W2950349721 cites W2074692187 @default.
- W2950349721 cites W2092191041 @default.
- W2950349721 cites W2094652341 @default.
- W2950349721 cites W2096248193 @default.
- W2950349721 cites W2098573845 @default.
- W2950349721 cites W2099085143 @default.
- W2950349721 cites W2100697281 @default.
- W2950349721 cites W2100965341 @default.
- W2950349721 cites W2102732029 @default.
- W2950349721 cites W2104989405 @default.
- W2950349721 cites W2105109817 @default.
- W2950349721 cites W2109938815 @default.
- W2950349721 cites W2111023308 @default.
- W2950349721 cites W2111340702 @default.
- W2950349721 cites W2113174452 @default.
- W2950349721 cites W2119004823 @default.
- W2950349721 cites W2123921851 @default.
- W2950349721 cites W2129316761 @default.
- W2950349721 cites W2133454964 @default.
- W2950349721 cites W2133520037 @default.
- W2950349721 cites W2136279532 @default.
- W2950349721 cites W2138998607 @default.
- W2950349721 cites W2139905203 @default.
- W2950349721 cites W2144961623 @default.
- W2950349721 cites W2147579012 @default.
- W2950349721 cites W2148895533 @default.
- W2950349721 cites W2150235363 @default.
- W2950349721 cites W2150651546 @default.