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- W2950354501 abstract "Abstract Erythrophleum alkaloid analogues, which differ in the ester side-chain configuration, in the nature of the 14-axial substituent (H, Me, Et) and in their absolute configuration, have been prepared. A pronounced trend towards increased Na+K+-ATPase inhibitory activity occurs through the H, Me and Et series, with the E side-chain configuration more active than the Z. This trend is largely confined to the analogues with an absolute configuration matching that of the natural alkaloids. A structural parallel between the 14-axial alkyl substituent of the alkaloids and the D-ring of the cardiotonic steroids is proposed." @default.
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- W2950354501 date "1991-09-01" @default.
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- W2950354501 title "Structural parallels between the cardiotonic steroids and the Erythrophleum alkaloids - II. Synthesis and Na+K+-ATPase inhibitory activity of novel Erythrophleum alkaloid analogues" @default.
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- W2950354501 doi "https://doi.org/10.1016/s0040-4020(01)81950-5" @default.
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