FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950356716> ?p ?o ?g. }

• W2950356716 endingPage "5431" @default.
• W2950356716 startingPage "5415" @default.
• W2950356716 abstract "Abstract The lung metastasis of breast cancer involves complicated regulatory changes driven by chromatin remodelling. However, the epigenetic reprogramming and regulatory mechanisms in lung metastasis of breast cancer remain unclear. Here, we generated and analysed genome‐wide profiles of multiple histone modifications (H3K4me3, H3K27ac, H3K27me3, H3K4me1 and H3K9me3), as well as transcriptome data in lung‐metastatic and non‐lung‐metastatic breast cancer cells. Our results showed that the expression changes were correlated with the enrichment of specific histone modifications in promoters and enhancers. Promoter and enhancer reprogramming regulated gene expression in a synergetic way, and involved in multiple important biological processes and pathways. In addition, lots of gained super‐enhancers were identified in lung‐metastatic cells. We also identified master regulators driving differential gene expression during lung metastasis of breast cancer. We found that the cooperations between regulators were much closer in lung‐metastatic cells. Moreover, regulators such as TFAP2C, GTF2I and LMO4 were found to have potential prognostic value for lung metastasis free (LMF) survival of breast cancer. Functional studies motivated by our data analyses uncovered an important role of LMO4 in regulating metastasis. This study provided comprehensive insights into regulatory mechanisms, as well as potential prognostic markers for lung metastasis of breast cancer." @default.
• W2950356716 created "2019-06-27" @default.
• W2950356716 creator A5012034438 @default.
• W2950356716 creator A5020513990 @default.
• W2950356716 creator A5022234807 @default.
• W2950356716 creator A5046182911 @default.
• W2950356716 creator A5048051556 @default.
• W2950356716 creator A5062315365 @default.
• W2950356716 date "2019-06-19" @default.
• W2950356716 modified "2023-10-18" @default.
• W2950356716 title "Comprehensive epigenetic analyses reveal master regulators driving lung metastasis of breast cancer" @default.
• W2950356716 cites W1830326861 @default.
• W2950356716 cites W1979821113 @default.
• W2950356716 cites W1987126775 @default.
• W2950356716 cites W2003338662 @default.
• W2950356716 cites W2006035096 @default.
• W2950356716 cites W2014677321 @default.
• W2950356716 cites W2021880490 @default.
• W2950356716 cites W2035131746 @default.
• W2950356716 cites W2060484997 @default.
• W2950356716 cites W2082833890 @default.
• W2950356716 cites W2083084802 @default.
• W2950356716 cites W2097092987 @default.
• W2950356716 cites W2098999612 @default.
• W2950356716 cites W2103017472 @default.
• W2950356716 cites W2117247812 @default.
• W2950356716 cites W2121624265 @default.
• W2950356716 cites W2133465414 @default.
• W2950356716 cites W2139794819 @default.
• W2950356716 cites W2140729960 @default.
• W2950356716 cites W2141458291 @default.
• W2950356716 cites W2150365399 @default.
• W2950356716 cites W2158217645 @default.
• W2950356716 cites W2159675211 @default.
• W2950356716 cites W2160641961 @default.
• W2950356716 cites W2163563958 @default.
• W2950356716 cites W2166820820 @default.
• W2950356716 cites W2170551349 @default.
• W2950356716 cites W2171808845 @default.
• W2950356716 cites W2295275561 @default.
• W2950356716 cites W2322132473 @default.
• W2950356716 cites W2397625098 @default.
• W2950356716 cites W2517609385 @default.
• W2950356716 cites W2559588208 @default.
• W2950356716 cites W2570618306 @default.
• W2950356716 cites W2588354379 @default.
• W2950356716 cites W2601176113 @default.
• W2950356716 cites W2604808360 @default.
• W2950356716 cites W2742000848 @default.
• W2950356716 cites W2766588110 @default.
• W2950356716 cites W2791701000 @default.
• W2950356716 cites W2806461678 @default.
• W2950356716 cites W2901738572 @default.
• W2950356716 cites W2918763371 @default.
• W2950356716 cites W991683603 @default.
• W2950356716 doi "https://doi.org/10.1111/jcmm.14424" @default.
• W2950356716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6653217" @default.
• W2950356716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31215771" @default.
• W2950356716 hasPublicationYear "2019" @default.
• W2950356716 type Work @default.
• W2950356716 sameAs 2950356716 @default.
• W2950356716 citedByCount "15" @default.
• W2950356716 countsByYear W29503567162020 @default.
• W2950356716 countsByYear W29503567162021 @default.
• W2950356716 countsByYear W29503567162022 @default.
• W2950356716 countsByYear W29503567162023 @default.
• W2950356716 crossrefType "journal-article" @default.
• W2950356716 hasAuthorship W2950356716A5012034438 @default.
• W2950356716 hasAuthorship W2950356716A5020513990 @default.
• W2950356716 hasAuthorship W2950356716A5022234807 @default.
• W2950356716 hasAuthorship W2950356716A5046182911 @default.
• W2950356716 hasAuthorship W2950356716A5048051556 @default.
• W2950356716 hasAuthorship W2950356716A5062315365 @default.
• W2950356716 hasBestOaLocation W29503567161 @default.
• W2950356716 hasConcept C101762097 @default.
• W2950356716 hasConcept C104317684 @default.
• W2950356716 hasConcept C111936080 @default.
• W2950356716 hasConcept C121608353 @default.
• W2950356716 hasConcept C121912465 @default.
• W2950356716 hasConcept C143998085 @default.
• W2950356716 hasConcept C1491633281 @default.
• W2950356716 hasConcept C150194340 @default.
• W2950356716 hasConcept C162317418 @default.
• W2950356716 hasConcept C165864922 @default.
• W2950356716 hasConcept C190727270 @default.
• W2950356716 hasConcept C2776256026 @default.
• W2950356716 hasConcept C2779013556 @default.
• W2950356716 hasConcept C2780914512 @default.
• W2950356716 hasConcept C41091548 @default.
• W2950356716 hasConcept C502942594 @default.
• W2950356716 hasConcept C530470458 @default.
• W2950356716 hasConcept C54355233 @default.
• W2950356716 hasConcept C64927066 @default.
• W2950356716 hasConcept C71924100 @default.
• W2950356716 hasConcept C77255625 @default.
• W2950356716 hasConcept C83640560 @default.
• W2950356716 hasConcept C86803240 @default.
• W2950356716 hasConceptScore W2950356716C101762097 @default.

• next