FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950357449> ?p ?o ?g. }

• W2950357449 endingPage "3034" @default.
• W2950357449 startingPage "3034" @default.
• W2950357449 abstract "Cisplatin is one of the major drugs used in oral cancer treatments, but its usage can be limited by acquired drug resistance. In this study, we established three cisplatin-resistant oral squamous cell carcinoma (OSCC) cell lines and characterized them using cell viability assays, qPCR, Western blotting, FACS, immunofluorescence, and wound healing assays. Three OSCC cell lines (YD-8, YD-9, and YD-38) underwent long-term exposure to cisplatin, eventually acquiring resistance to the drug, which was confirmed by an MTT assay. In these three newly established cell lines (YD-8/CIS, YD-9/CIS, and YD-38/CIS), overexpression of multidrug resistance (MDR)-related genes was detected by qPCR and Western blotting. The cell lines displayed an increase in the functional activities of breast cancer resistance protein (BCRP) and multidrug resistance protein1 (MDR1) by rhodamine 123 and bodipy FL prazosin accumulation assays. Moreover, the cisplatin-resistant cells underwent morphological changes, from round to spindle-shaped, increased expression of epithelial-to-mesenchymal transition (EMT)-related molecules such as N-cadherin, and showed increased cell migration when compared with the parental cell lines. These results suggest that these newly established cell lines have acquired drug resistance and EMT induction." @default.
• W2950357449 created "2019-06-27" @default.
• W2950357449 creator A5002694025 @default.
• W2950357449 creator A5008683169 @default.
• W2950357449 creator A5057877443 @default.
• W2950357449 date "2019-06-21" @default.
• W2950357449 modified "2023-10-16" @default.
• W2950357449 title "Upregulation of MDR- and EMT-Related Molecules in Cisplatin-Resistant Human Oral Squamous Cell Carcinoma Cell Lines" @default.
• W2950357449 cites W1522997539 @default.
• W2950357449 cites W1678477795 @default.
• W2950357449 cites W1981140460 @default.
• W2950357449 cites W1984559226 @default.
• W2950357449 cites W1993184426 @default.
• W2950357449 cites W2000825690 @default.
• W2950357449 cites W2005866855 @default.
• W2950357449 cites W2022152336 @default.
• W2950357449 cites W2038670536 @default.
• W2950357449 cites W2047172303 @default.
• W2950357449 cites W2049135632 @default.
• W2950357449 cites W2072046272 @default.
• W2950357449 cites W2107277218 @default.
• W2950357449 cites W2119983127 @default.
• W2950357449 cites W2140744545 @default.
• W2950357449 cites W2141037581 @default.
• W2950357449 cites W2178203671 @default.
• W2950357449 cites W2185052970 @default.
• W2950357449 cites W2192080449 @default.
• W2950357449 cites W2269229989 @default.
• W2950357449 cites W2299688195 @default.
• W2950357449 cites W2308408790 @default.
• W2950357449 cites W2381727044 @default.
• W2950357449 cites W2465912477 @default.
• W2950357449 cites W2500192509 @default.
• W2950357449 cites W2552820307 @default.
• W2950357449 cites W2565536031 @default.
• W2950357449 cites W2643282900 @default.
• W2950357449 cites W2740324734 @default.
• W2950357449 cites W2763165573 @default.
• W2950357449 cites W2768008085 @default.
• W2950357449 cites W2769429303 @default.
• W2950357449 cites W2898392093 @default.
• W2950357449 cites W2903212105 @default.
• W2950357449 doi "https://doi.org/10.3390/ijms20123034" @default.
• W2950357449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6627081" @default.
• W2950357449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31234332" @default.
• W2950357449 hasPublicationYear "2019" @default.
• W2950357449 type Work @default.
• W2950357449 sameAs 2950357449 @default.
• W2950357449 citedByCount "23" @default.
• W2950357449 countsByYear W29503574492019 @default.
• W2950357449 countsByYear W29503574492020 @default.
• W2950357449 countsByYear W29503574492021 @default.
• W2950357449 countsByYear W29503574492022 @default.
• W2950357449 countsByYear W29503574492023 @default.
• W2950357449 crossrefType "journal-article" @default.
• W2950357449 hasAuthorship W2950357449A5002694025 @default.
• W2950357449 hasAuthorship W2950357449A5008683169 @default.
• W2950357449 hasAuthorship W2950357449A5057877443 @default.
• W2950357449 hasBestOaLocation W29503574491 @default.
• W2950357449 hasConcept C104317684 @default.
• W2950357449 hasConcept C114851261 @default.
• W2950357449 hasConcept C127561419 @default.
• W2950357449 hasConcept C133936738 @default.
• W2950357449 hasConcept C1491633281 @default.
• W2950357449 hasConcept C153911025 @default.
• W2950357449 hasConcept C2776694085 @default.
• W2950357449 hasConcept C2778239845 @default.
• W2950357449 hasConcept C2778589691 @default.
• W2950357449 hasConcept C2780783641 @default.
• W2950357449 hasConcept C502942594 @default.
• W2950357449 hasConcept C53227056 @default.
• W2950357449 hasConcept C54355233 @default.
• W2950357449 hasConcept C55493867 @default.
• W2950357449 hasConcept C76419328 @default.
• W2950357449 hasConcept C81885089 @default.
• W2950357449 hasConcept C85265743 @default.
• W2950357449 hasConcept C86803240 @default.
• W2950357449 hasConcept C89423630 @default.
• W2950357449 hasConceptScore W2950357449C104317684 @default.
• W2950357449 hasConceptScore W2950357449C114851261 @default.
• W2950357449 hasConceptScore W2950357449C127561419 @default.
• W2950357449 hasConceptScore W2950357449C133936738 @default.
• W2950357449 hasConceptScore W2950357449C1491633281 @default.
• W2950357449 hasConceptScore W2950357449C153911025 @default.
• W2950357449 hasConceptScore W2950357449C2776694085 @default.
• W2950357449 hasConceptScore W2950357449C2778239845 @default.
• W2950357449 hasConceptScore W2950357449C2778589691 @default.
• W2950357449 hasConceptScore W2950357449C2780783641 @default.
• W2950357449 hasConceptScore W2950357449C502942594 @default.
• W2950357449 hasConceptScore W2950357449C53227056 @default.
• W2950357449 hasConceptScore W2950357449C54355233 @default.
• W2950357449 hasConceptScore W2950357449C55493867 @default.
• W2950357449 hasConceptScore W2950357449C76419328 @default.
• W2950357449 hasConceptScore W2950357449C81885089 @default.
• W2950357449 hasConceptScore W2950357449C85265743 @default.
• W2950357449 hasConceptScore W2950357449C86803240 @default.
• W2950357449 hasConceptScore W2950357449C89423630 @default.
• W2950357449 hasIssue "12" @default.

• next