Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950359634> ?p ?o ?g. }
- W2950359634 abstract "Abstract Genome-wide association studies (GWAS) have identified over 41 susceptibility loci associated with Parkinson’s Disease (PD) but identifying putative causal genes and the underlying mechanisms remains challenging. Here, we leverage large-scale transcriptomic datasets to prioritize genes that are likely to affect PD by using a transcriptome-wide association study (TWAS) approach. Using this approach, we identify 66 gene associations whose predicted expression or splicing levels in dorsolateral prefrontal cortex (DLFPC) and peripheral monocytes are significantly associated with PD risk. We uncover many novel genes associated with PD but also novel mechanisms for known associations such as MAPT , for which we find that variation in exon 3 splicing explains the common genetic association. Genes identified in our analyses belong to the same or related pathways including lysosomal and innate immune function. Overall, our study provides a strong foundation for further mechanistic studies that will elucidate the molecular drivers of PD." @default.
- W2950359634 created "2019-06-27" @default.
- W2950359634 creator A5001322329 @default.
- W2950359634 creator A5050747458 @default.
- W2950359634 creator A5064842058 @default.
- W2950359634 creator A5081262341 @default.
- W2950359634 date "2019-03-01" @default.
- W2950359634 modified "2023-10-16" @default.
- W2950359634 title "Prioritizing Parkinson’s disease genes using population-scale transcriptomic data" @default.
- W2950359634 cites W1533942137 @default.
- W2950359634 cites W1907174433 @default.
- W2950359634 cites W1964467356 @default.
- W2950359634 cites W1965546358 @default.
- W2950359634 cites W1966116114 @default.
- W2950359634 cites W1967588638 @default.
- W2950359634 cites W1973114784 @default.
- W2950359634 cites W1977099733 @default.
- W2950359634 cites W1983643492 @default.
- W2950359634 cites W1990844894 @default.
- W2950359634 cites W2004950789 @default.
- W2950359634 cites W2011200428 @default.
- W2950359634 cites W2012697072 @default.
- W2950359634 cites W2027588127 @default.
- W2950359634 cites W2033105784 @default.
- W2950359634 cites W2033151532 @default.
- W2950359634 cites W2050786534 @default.
- W2950359634 cites W2059742736 @default.
- W2950359634 cites W2066866161 @default.
- W2950359634 cites W2073836327 @default.
- W2950359634 cites W2074405990 @default.
- W2950359634 cites W2094379190 @default.
- W2950359634 cites W2101280135 @default.
- W2950359634 cites W2104261859 @default.
- W2950359634 cites W2106158921 @default.
- W2950359634 cites W2115779804 @default.
- W2950359634 cites W2124655419 @default.
- W2950359634 cites W2124940469 @default.
- W2950359634 cites W2125972459 @default.
- W2950359634 cites W2127063807 @default.
- W2950359634 cites W2136273720 @default.
- W2950359634 cites W2141459724 @default.
- W2950359634 cites W2152885121 @default.
- W2950359634 cites W2156168338 @default.
- W2950359634 cites W2163286288 @default.
- W2950359634 cites W2209106767 @default.
- W2950359634 cites W2214198121 @default.
- W2950359634 cites W2221356560 @default.
- W2950359634 cites W2241686927 @default.
- W2950359634 cites W2264585211 @default.
- W2950359634 cites W2344561059 @default.
- W2950359634 cites W2503832164 @default.
- W2950359634 cites W2512410446 @default.
- W2950359634 cites W2526546796 @default.
- W2950359634 cites W2531792466 @default.
- W2950359634 cites W2550954689 @default.
- W2950359634 cites W2553059833 @default.
- W2950359634 cites W2602156859 @default.
- W2950359634 cites W2619332462 @default.
- W2950359634 cites W2754278602 @default.
- W2950359634 cites W2774883395 @default.
- W2950359634 cites W2893655504 @default.
- W2950359634 cites W2896339946 @default.
- W2950359634 cites W2914899943 @default.
- W2950359634 cites W2949785910 @default.
- W2950359634 cites W2950649723 @default.
- W2950359634 cites W2951325776 @default.
- W2950359634 cites W2952898251 @default.
- W2950359634 cites W2953357410 @default.
- W2950359634 doi "https://doi.org/10.1038/s41467-019-08912-9" @default.
- W2950359634 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6397174" @default.
- W2950359634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30824768" @default.
- W2950359634 hasPublicationYear "2019" @default.
- W2950359634 type Work @default.
- W2950359634 sameAs 2950359634 @default.
- W2950359634 citedByCount "113" @default.
- W2950359634 countsByYear W29503596342019 @default.
- W2950359634 countsByYear W29503596342020 @default.
- W2950359634 countsByYear W29503596342021 @default.
- W2950359634 countsByYear W29503596342022 @default.
- W2950359634 countsByYear W29503596342023 @default.
- W2950359634 crossrefType "journal-article" @default.
- W2950359634 hasAuthorship W2950359634A5001322329 @default.
- W2950359634 hasAuthorship W2950359634A5050747458 @default.
- W2950359634 hasAuthorship W2950359634A5064842058 @default.
- W2950359634 hasAuthorship W2950359634A5081262341 @default.
- W2950359634 hasBestOaLocation W29503596341 @default.
- W2950359634 hasConcept C104317684 @default.
- W2950359634 hasConcept C106208931 @default.
- W2950359634 hasConcept C135763542 @default.
- W2950359634 hasConcept C142724271 @default.
- W2950359634 hasConcept C150194340 @default.
- W2950359634 hasConcept C153209595 @default.
- W2950359634 hasConcept C162317418 @default.
- W2950359634 hasConcept C186413461 @default.
- W2950359634 hasConcept C194583182 @default.
- W2950359634 hasConcept C2779134260 @default.
- W2950359634 hasConcept C36823959 @default.
- W2950359634 hasConcept C54355233 @default.
- W2950359634 hasConcept C69991583 @default.
- W2950359634 hasConcept C70721500 @default.