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• W2950362205 abstract "Air pollution affects the pathophysiology of gastrointestinal tract and has been linked to several gastrointestinal diseases in recent years. However, little is known about the association of air pollution with peptic ulcer bleeding (PUB). We aimed to conduct a time-series study to examine the association between short-term exposure to fine particulate matter (PM2.5) and emergency admissions for PUB in Beijing, China. Data on emergency admissions for PUB between January 1, 2010, and June 30, 2012 were obtained from the Beijing Medical Claim Data for Employees. Measurements of PM2.5 concentration were obtained from the United States Embassy air-monitoring station. A generalized additive Poisson model was applied to explore the association between PM2.5 concentrations and emergency admissions for PUB, with stratification by gender and age. A total of 5123 emergency admissions for PUB were identified. Short-term exposure to outdoor PM2.5 was significantly associated with increased emergency admissions for PUB at lag0 day. A 10 μg/m3 increase in PM2.5 concentration at lag0 day corresponded to a 0.56% (95% confidence interval (CI) 0.04%–1.08%; P = 0.035) increase in emergency admissions for PUB. There was a clear concentration-response association between PM2.5 concentrations and emergency admissions for PUB. The PM2.5 effect estimates were greater in elderly people (≥65 years old) with the difference approaching statistical significance (percentage change 0.78, 95% CI 0.03%–1.54% in patients ≥65 years old; percentage change 0.32, 95% CI -0.38%–1.03% in patients <65 years old; P = 0.073), but the difference between men and women was not significant (percentage change 0.75, 95% CI 0.08%–1.43% in man; percentage change 0.27, 95% CI -0.51%–1.07% in woman; P = 0.368). Short-term elevation in outdoor PM2.5 concentrations was associated with increased emergency admissions for PUB, particularly in elderly people. Future studies are warranted to confirm the findings and elucidate the mechanisms underlying the association." @default.
• W2950362205 created "2019-06-27" @default.
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• W2950362205 date "2019-09-01" @default.
• W2950362205 modified "2023-09-24" @default.
• W2950362205 title "Exploring the association between short-term exposure to ambient fine particulate matter pollution and emergency admissions for peptic ulcer bleeding in Beijing, China" @default.
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• W2950362205 doi "https://doi.org/10.1016/j.atmosenv.2019.06.037" @default.
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