FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950363407> ?p ?o ?g. }

• W2950363407 abstract "Abstract Plants produce a tremendous diversity of specialized metabolites (SMs) to interact with and manage their environment. A major challenge hindering efforts to tap this seemingly boundless source of pharmacopeia is the identification of SM pathways and their constituent genes. Given the well-established observation that the genes comprising a SM pathway are co-regulated in response to specific environmental conditions, we hypothesized that genes from a given SM pathway would form tight associations (modules) with each other in gene co-expression networks, facilitating their identification. To evaluate this hypothesis, we used 10 global co-expression datasets—each a meta-analysis of hundreds to thousands of expression experiments—across eight plant model organisms to identify hundreds of modules of co-expressed genes for each species. In support of our hypothesis, 15.3-52.6% of modules contained two or more known SM biosynthetic genes (e.g., cytochrome P450s, terpene synthases, and chalcone synthases), and module genes were enriched in SM functions (e.g., glucoside and flavonoid biosynthesis). Moreover, modules recovered many experimentally validated SM pathways in these plants, including all six known to form biosynthetic gene clusters (BGCs). In contrast, genes predicted based on physical proximity on a chromosome to form plant BGCs were no more co-expressed than the null distribution for neighboring genes. These results not only suggest that most predicted plant BGCs do not represent genuine SM pathways but also argue that BGCs are unlikely to be a hallmark of plant specialized metabolism. We submit that global gene co-expression is a rich, but largely untapped, data source for discovering the genetic basis and architecture of plant natural products, which can be applied even without knowledge of the genome sequence." @default.
• W2950363407 created "2019-06-27" @default.
• W2950363407 creator A5029387644 @default.
• W2950363407 creator A5034503245 @default.
• W2950363407 creator A5046883178 @default.
• W2950363407 creator A5050894444 @default.
• W2950363407 creator A5056340154 @default.
• W2950363407 creator A5086006151 @default.
• W2950363407 date "2016-12-14" @default.
• W2950363407 modified "2023-10-10" @default.
• W2950363407 title "A global co-expression network approach for connecting genes to specialized metabolic pathways in plants" @default.
• W2950363407 cites W1830282417 @default.
• W2950363407 cites W1837548183 @default.
• W2950363407 cites W1908709110 @default.
• W2950363407 cites W1964408683 @default.
• W2950363407 cites W1966794959 @default.
• W2950363407 cites W1968216644 @default.
• W2950363407 cites W1971430242 @default.
• W2950363407 cites W1978242826 @default.
• W2950363407 cites W1987088602 @default.
• W2950363407 cites W1992581858 @default.
• W2950363407 cites W1999498230 @default.
• W2950363407 cites W2001217529 @default.
• W2950363407 cites W2009204329 @default.
• W2950363407 cites W2009257824 @default.
• W2950363407 cites W2012598119 @default.
• W2950363407 cites W2018598385 @default.
• W2950363407 cites W2033089875 @default.
• W2950363407 cites W2038629676 @default.
• W2950363407 cites W2042599561 @default.
• W2950363407 cites W2049435776 @default.
• W2950363407 cites W2050283923 @default.
• W2950363407 cites W2051263494 @default.
• W2950363407 cites W2059861223 @default.
• W2950363407 cites W2060036564 @default.
• W2950363407 cites W2066063022 @default.
• W2950363407 cites W2071342447 @default.
• W2950363407 cites W2072847924 @default.
• W2950363407 cites W2072966557 @default.
• W2950363407 cites W2073205409 @default.
• W2950363407 cites W2073430126 @default.
• W2950363407 cites W2077979680 @default.
• W2950363407 cites W2078689865 @default.
• W2950363407 cites W2082565035 @default.
• W2950363407 cites W2083711705 @default.
• W2950363407 cites W2086867029 @default.
• W2950363407 cites W2086953382 @default.
• W2950363407 cites W2089032501 @default.
• W2950363407 cites W2096316585 @default.
• W2950363407 cites W2097749211 @default.
• W2950363407 cites W2104693064 @default.
• W2950363407 cites W2109385242 @default.
• W2950363407 cites W2113861951 @default.
• W2950363407 cites W2115579638 @default.
• W2950363407 cites W2117787079 @default.
• W2950363407 cites W2119180692 @default.
• W2950363407 cites W2122221811 @default.
• W2950363407 cites W2128601422 @default.
• W2950363407 cites W2134990135 @default.
• W2950363407 cites W2140032126 @default.
• W2950363407 cites W2146097252 @default.
• W2950363407 cites W2148556623 @default.
• W2950363407 cites W2149591934 @default.
• W2950363407 cites W2150283664 @default.
• W2950363407 cites W2153702005 @default.
• W2950363407 cites W2157759979 @default.
• W2950363407 cites W2158941576 @default.
• W2950363407 cites W2160201278 @default.
• W2950363407 cites W2164689525 @default.
• W2950363407 cites W2165442817 @default.
• W2950363407 cites W2167455933 @default.
• W2950363407 cites W2167719653 @default.
• W2950363407 cites W2170455232 @default.
• W2950363407 cites W2190741296 @default.
• W2950363407 cites W2207046140 @default.
• W2950363407 cites W2249261020 @default.
• W2950363407 cites W2285514562 @default.
• W2950363407 cites W2320337426 @default.
• W2950363407 cites W2344104081 @default.
• W2950363407 cites W2422187287 @default.
• W2950363407 cites W2466338408 @default.
• W2950363407 cites W2520377469 @default.
• W2950363407 cites W2528366928 @default.
• W2950363407 cites W2552766887 @default.
• W2950363407 cites W2552968665 @default.
• W2950363407 cites W2559713102 @default.
• W2950363407 cites W2595793279 @default.
• W2950363407 doi "https://doi.org/10.1101/093914" @default.
• W2950363407 hasPublicationYear "2016" @default.
• W2950363407 type Work @default.
• W2950363407 sameAs 2950363407 @default.
• W2950363407 citedByCount "3" @default.
• W2950363407 countsByYear W29503634072017 @default.
• W2950363407 countsByYear W29503634072018 @default.
• W2950363407 crossrefType "posted-content" @default.
• W2950363407 hasAuthorship W2950363407A5029387644 @default.
• W2950363407 hasAuthorship W2950363407A5034503245 @default.
• W2950363407 hasAuthorship W2950363407A5046883178 @default.
• W2950363407 hasAuthorship W2950363407A5050894444 @default.
• W2950363407 hasAuthorship W2950363407A5056340154 @default.

• next