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- W2950368198 endingPage "418" @default.
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- W2950368198 abstract "The tumor microenvironment (TME) is composed of dynamic and complex networks composed of matrix substrates, extracellular matrix (ECM), non-malignant cells, and tumor cells. The TME is in constant evolution during the disease progression, most notably through gradual stiffening of the stroma. Within the tumor, increased ECM stiffness drives tumor growth and metastatic events. However, classic in vitro strategies to study the TME in cancer lack the complexity to fully replicate the TME. The quest to understand how the mechanical, geometrical, and biochemical environment of cells impacts their behavior and fate has been a major force driving the recent development of new technologies in cell biology research. Despite rapid advances in this field, many challenges remain in order to bridge the gap between the classical culture dish and the biological reality of actual tissue. Microfabrication coupled with microfluidic approaches aim to engineer the actual complexity of the TME. Moreover, TME bioengineering allows artificial modulations with single or multiple cues to study different phenomena occurring in vivo. Some innovative cutting-edge tools and new microfluidic approaches could have an important impact on the fields of biology and medicine by bringing deeper understanding of the TME, cell behavior, and drug effects." @default.
- W2950368198 created "2019-06-27" @default.
- W2950368198 creator A5006527021 @default.
- W2950368198 creator A5009980051 @default.
- W2950368198 creator A5053144955 @default.
- W2950368198 creator A5086297111 @default.
- W2950368198 date "2019-06-22" @default.
- W2950368198 modified "2023-10-13" @default.
- W2950368198 title "Coupling Microfluidic Platforms, Microfabrication, and Tissue Engineered Scaffolds to Investigate Tumor Cells Mechanobiology" @default.
- W2950368198 cites W1493975488 @default.
- W2950368198 cites W1504068356 @default.
- W2950368198 cites W1762951073 @default.
- W2950368198 cites W1781255194 @default.
- W2950368198 cites W18036118 @default.
- W2950368198 cites W1901255537 @default.
- W2950368198 cites W1964128680 @default.
- W2950368198 cites W1970505421 @default.
- W2950368198 cites W1971116628 @default.
- W2950368198 cites W1972825083 @default.
- W2950368198 cites W1974084988 @default.
- W2950368198 cites W1976709402 @default.
- W2950368198 cites W1976896311 @default.
- W2950368198 cites W1983594330 @default.
- W2950368198 cites W1986557818 @default.
- W2950368198 cites W1991298929 @default.
- W2950368198 cites W1992112921 @default.
- W2950368198 cites W1993294045 @default.
- W2950368198 cites W1996757213 @default.
- W2950368198 cites W1999133016 @default.
- W2950368198 cites W2008324315 @default.
- W2950368198 cites W2008434550 @default.
- W2950368198 cites W2010251891 @default.
- W2950368198 cites W2012628829 @default.
- W2950368198 cites W2017786762 @default.
- W2950368198 cites W2023098178 @default.
- W2950368198 cites W2025194201 @default.
- W2950368198 cites W2031708844 @default.
- W2950368198 cites W2039414616 @default.
- W2950368198 cites W2044054332 @default.
- W2950368198 cites W2044278480 @default.
- W2950368198 cites W2044835625 @default.
- W2950368198 cites W2045864764 @default.
- W2950368198 cites W2046643396 @default.
- W2950368198 cites W2050541281 @default.
- W2950368198 cites W2051560355 @default.
- W2950368198 cites W2055091294 @default.
- W2950368198 cites W2057917964 @default.
- W2950368198 cites W2060672294 @default.
- W2950368198 cites W2062653552 @default.
- W2950368198 cites W2065890885 @default.
- W2950368198 cites W2069977719 @default.
- W2950368198 cites W2073137330 @default.
- W2950368198 cites W2073290778 @default.
- W2950368198 cites W2086886614 @default.
- W2950368198 cites W2098947128 @default.
- W2950368198 cites W2099052265 @default.
- W2950368198 cites W2100122781 @default.
- W2950368198 cites W2100303404 @default.
- W2950368198 cites W2101167135 @default.
- W2950368198 cites W2101659933 @default.
- W2950368198 cites W2110344693 @default.
- W2950368198 cites W2113220609 @default.
- W2950368198 cites W2117692326 @default.
- W2950368198 cites W2118278569 @default.
- W2950368198 cites W2118924756 @default.
- W2950368198 cites W2122920174 @default.
- W2950368198 cites W2123232388 @default.
- W2950368198 cites W2134044673 @default.
- W2950368198 cites W2137034111 @default.
- W2950368198 cites W2140445067 @default.
- W2950368198 cites W2140821709 @default.
- W2950368198 cites W2148583918 @default.
- W2950368198 cites W2152041843 @default.
- W2950368198 cites W2155741453 @default.
- W2950368198 cites W2157765551 @default.
- W2950368198 cites W2165064029 @default.
- W2950368198 cites W2171187117 @default.
- W2950368198 cites W2181940539 @default.
- W2950368198 cites W2193901161 @default.
- W2950368198 cites W2208179253 @default.
- W2950368198 cites W2214946770 @default.
- W2950368198 cites W2215759309 @default.
- W2950368198 cites W2283766199 @default.
- W2950368198 cites W2297776087 @default.
- W2950368198 cites W2311649981 @default.
- W2950368198 cites W2320547225 @default.
- W2950368198 cites W232770196 @default.
- W2950368198 cites W2327958006 @default.
- W2950368198 cites W2337230445 @default.
- W2950368198 cites W2345307871 @default.
- W2950368198 cites W2347105079 @default.
- W2950368198 cites W2362472408 @default.
- W2950368198 cites W2400149108 @default.
- W2950368198 cites W2407256458 @default.
- W2950368198 cites W2408251441 @default.
- W2950368198 cites W2416816599 @default.
- W2950368198 cites W2460593466 @default.
- W2950368198 cites W2464386848 @default.