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• W2950382922 abstract "Stimuli-responsive hydrogel matrices are inspiring manifold applications in controlled delivery of bioactive compounds. Elastin-derived polypeptides form hydrogel matrices that may release bioactive moieties as a function of local increase of active elastases, as it would occur in several processes like inflammation. In view of the development of a patch for healing wounds, recombinant elastin-based polypeptides were combined with a proteolysis-resistant scaffold, made of electrospun poly-L-lactic acid (PLLA) fibers. The results of this study demonstrated the compatibility of these two components. An efficient procedure to obtain a composite material retaining the main features of each component was established. The release of the elastin moiety was monitored by means of a simple protocol. Our data showed that electrospun poly-L-lactic acid (PLLA) can form a composite with fusion proteins bound to elastin-derived polypeptides. Therefore, our approach allows designing a therapeutic agent delivery platform to realize devices capable of responding and interacting with biological systems at the molecular level." @default.
• W2950382922 created "2019-06-27" @default.
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• W2950382922 date "2018-09-12" @default.
• W2950382922 modified "2023-10-10" @default.
• W2950382922 title "Composite of Elastin-Based Matrix and Electrospun Poly(L-Lactic Acid) Fibers: A Potential Smart Drug Delivery System" @default.
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• W2950382922 doi "https://doi.org/10.3389/fbioe.2018.00127" @default.
• W2950382922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6143670" @default.
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