FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950386747> ?p ?o ?g. }

• W2950386747 endingPage "1781" @default.
• W2950386747 startingPage "1765" @default.
• W2950386747 abstract "Over the past decade, continuous wet granulation has been emerging as a promising technology in drug product development. In this paper, the continuous high-shear mixer granulator, Lӧdige CoriMix® CM5, was investigated using a low-dose formulation with acetaminophen as the model drug. Design of experiments was deployed in conjunction with multivariate data analysis to explore the granulator design space and comprehensively understand the interrelation between process parameters and critical attributes of granules and tablets. Moreover, several complementary imaging techniques were implemented to unveil the underlying mechanisms of physical and chemical microstructure in affecting the tablet performance. The results indicated that L/S ratio and impeller speed outweighed materials feeding rate in modifying the granule and tablet properties. Increasing the degree of liquid saturation and mechanical shear input in the granulation system principally produced granules of larger size, smaller porosity, improved flowability and enhanced sphericity, which after compression generated tablets with slower disintegration process and drug release kinetics due to highly consolidated physical microstructure. Besides, in comparison to batch mixing, continuous mixing integrated with a conical mill enabled better powder de-agglomeration effect, thus accelerating the drug dissolution with increased surface area." @default.
• W2950386747 created "2019-06-27" @default.
• W2950386747 creator A5002781511 @default.
• W2950386747 creator A5043154303 @default.
• W2950386747 creator A5046787900 @default.
• W2950386747 creator A5082076422 @default.
• W2950386747 creator A5082124093 @default.
• W2950386747 creator A5083875048 @default.
• W2950386747 creator A5089802411 @default.
• W2950386747 date "2019-09-01" @default.
• W2950386747 modified "2023-09-26" @default.
• W2950386747 title "Continuous high-shear granulation: Mechanistic understanding of the influence of process parameters on critical quality attributes via elucidating the internal physical and chemical microstructure" @default.
• W2950386747 cites W1770883461 @default.
• W2950386747 cites W1848367875 @default.
• W2950386747 cites W1977091953 @default.
• W2950386747 cites W1988673523 @default.
• W2950386747 cites W1991618236 @default.
• W2950386747 cites W1993692829 @default.
• W2950386747 cites W1997791831 @default.
• W2950386747 cites W1998089412 @default.
• W2950386747 cites W1999481657 @default.
• W2950386747 cites W2005678162 @default.
• W2950386747 cites W2023117736 @default.
• W2950386747 cites W2030981558 @default.
• W2950386747 cites W2045428417 @default.
• W2950386747 cites W2046423343 @default.
• W2950386747 cites W2048456835 @default.
• W2950386747 cites W2067470496 @default.
• W2950386747 cites W2075000410 @default.
• W2950386747 cites W2081513817 @default.
• W2950386747 cites W2082458302 @default.
• W2950386747 cites W2115439624 @default.
• W2950386747 cites W2166283053 @default.
• W2950386747 cites W2218157908 @default.
• W2950386747 cites W2464666597 @default.
• W2950386747 cites W2520104203 @default.
• W2950386747 cites W2609181361 @default.
• W2950386747 cites W2802759018 @default.
• W2950386747 cites W2904797069 @default.
• W2950386747 doi "https://doi.org/10.1016/j.apt.2019.04.028" @default.
• W2950386747 hasPublicationYear "2019" @default.
• W2950386747 type Work @default.
• W2950386747 sameAs 2950386747 @default.
• W2950386747 citedByCount "5" @default.
• W2950386747 countsByYear W29503867472020 @default.
• W2950386747 countsByYear W29503867472021 @default.
• W2950386747 countsByYear W29503867472022 @default.
• W2950386747 countsByYear W29503867472023 @default.
• W2950386747 crossrefType "journal-article" @default.
• W2950386747 hasAuthorship W2950386747A5002781511 @default.
• W2950386747 hasAuthorship W2950386747A5043154303 @default.
• W2950386747 hasAuthorship W2950386747A5046787900 @default.
• W2950386747 hasAuthorship W2950386747A5082076422 @default.
• W2950386747 hasAuthorship W2950386747A5082124093 @default.
• W2950386747 hasAuthorship W2950386747A5083875048 @default.
• W2950386747 hasAuthorship W2950386747A5089802411 @default.
• W2950386747 hasConcept C127413603 @default.
• W2950386747 hasConcept C159985019 @default.
• W2950386747 hasConcept C173913448 @default.
• W2950386747 hasConcept C187530423 @default.
• W2950386747 hasConcept C191168616 @default.
• W2950386747 hasConcept C192562407 @default.
• W2950386747 hasConcept C21880701 @default.
• W2950386747 hasConcept C2776035855 @default.
• W2950386747 hasConcept C2780449318 @default.
• W2950386747 hasConcept C42360764 @default.
• W2950386747 hasConcept C49760210 @default.
• W2950386747 hasConcept C521977710 @default.
• W2950386747 hasConcept C6648577 @default.
• W2950386747 hasConcept C87976508 @default.
• W2950386747 hasConcept C88380143 @default.
• W2950386747 hasConcept C88463166 @default.
• W2950386747 hasConceptScore W2950386747C127413603 @default.
• W2950386747 hasConceptScore W2950386747C159985019 @default.
• W2950386747 hasConceptScore W2950386747C173913448 @default.
• W2950386747 hasConceptScore W2950386747C187530423 @default.
• W2950386747 hasConceptScore W2950386747C191168616 @default.
• W2950386747 hasConceptScore W2950386747C192562407 @default.
• W2950386747 hasConceptScore W2950386747C21880701 @default.
• W2950386747 hasConceptScore W2950386747C2776035855 @default.
• W2950386747 hasConceptScore W2950386747C2780449318 @default.
• W2950386747 hasConceptScore W2950386747C42360764 @default.
• W2950386747 hasConceptScore W2950386747C49760210 @default.
• W2950386747 hasConceptScore W2950386747C521977710 @default.
• W2950386747 hasConceptScore W2950386747C6648577 @default.
• W2950386747 hasConceptScore W2950386747C87976508 @default.
• W2950386747 hasConceptScore W2950386747C88380143 @default.
• W2950386747 hasConceptScore W2950386747C88463166 @default.
• W2950386747 hasIssue "9" @default.
• W2950386747 hasLocation W29503867471 @default.
• W2950386747 hasOpenAccess W2950386747 @default.
• W2950386747 hasPrimaryLocation W29503867471 @default.
• W2950386747 hasRelatedWork W2075000410 @default.
• W2950386747 hasRelatedWork W2077885684 @default.
• W2950386747 hasRelatedWork W2094064925 @default.
• W2950386747 hasRelatedWork W2505829942 @default.
• W2950386747 hasRelatedWork W2802759018 @default.
• W2950386747 hasRelatedWork W2981845340 @default.

• next