Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950393634> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2950393634 abstract "Proteins appear to be the most dramatic natural example of self-organized criticality (SOC), a concept that explains many otherwise apparently unlikely phenomena. Protein conformational functionality is often dominated by long-range hydro(phobic/philic) interactions which both drive protein compaction and mediate protein-protein interactions. Superfamily transmembrane GPCR are the largest family of proteins in the human genome; their amino acid sequences form the largest data base for protein-membrane interactions. While there are now structural data on the heptad transmembrane structures of representatives of several heptad families, here we show that fresh insights into global and some local chemical trends in GPCR properties can be obtained accurately from sequences alone, especially by separating the extracellular and cytoplasmic loops from transmembrane segments. The global mediation of long-range water-protein interactions occurs in conjunction with modulation of these interactions by roughened interfaces. Hydropathic roughening profiles are defined here solely in terms of amino acid sequences, and knowledge of protein coordinates is not required. Roughening profiles both for GPCR and some simpler protein families display accurate and transparent connections to protein functionality." @default.
- W2950393634 created "2019-06-27" @default.
- W2950393634 creator A5086916844 @default.
- W2950393634 date "2010-11-18" @default.
- W2950393634 modified "2023-09-26" @default.
- W2950393634 title "Self-Organized Criticality in Proteins: Hydropathic Roughening Profiles of G-Protein Coupled Receptors" @default.
- W2950393634 doi "https://doi.org/10.48550/arxiv.1011.4286" @default.
- W2950393634 hasPublicationYear "2010" @default.
- W2950393634 type Work @default.
- W2950393634 sameAs 2950393634 @default.
- W2950393634 citedByCount "1" @default.
- W2950393634 countsByYear W29503936342012 @default.
- W2950393634 crossrefType "posted-content" @default.
- W2950393634 hasAuthorship W2950393634A5086916844 @default.
- W2950393634 hasBestOaLocation W29503936341 @default.
- W2950393634 hasConcept C104317684 @default.
- W2950393634 hasConcept C11804247 @default.
- W2950393634 hasConcept C118892022 @default.
- W2950393634 hasConcept C12554922 @default.
- W2950393634 hasConcept C135285700 @default.
- W2950393634 hasConcept C144647389 @default.
- W2950393634 hasConcept C170493617 @default.
- W2950393634 hasConcept C171897839 @default.
- W2950393634 hasConcept C185592680 @default.
- W2950393634 hasConcept C24530287 @default.
- W2950393634 hasConcept C41625074 @default.
- W2950393634 hasConcept C47701112 @default.
- W2950393634 hasConcept C515207424 @default.
- W2950393634 hasConcept C55493867 @default.
- W2950393634 hasConcept C70721500 @default.
- W2950393634 hasConcept C86803240 @default.
- W2950393634 hasConceptScore W2950393634C104317684 @default.
- W2950393634 hasConceptScore W2950393634C11804247 @default.
- W2950393634 hasConceptScore W2950393634C118892022 @default.
- W2950393634 hasConceptScore W2950393634C12554922 @default.
- W2950393634 hasConceptScore W2950393634C135285700 @default.
- W2950393634 hasConceptScore W2950393634C144647389 @default.
- W2950393634 hasConceptScore W2950393634C170493617 @default.
- W2950393634 hasConceptScore W2950393634C171897839 @default.
- W2950393634 hasConceptScore W2950393634C185592680 @default.
- W2950393634 hasConceptScore W2950393634C24530287 @default.
- W2950393634 hasConceptScore W2950393634C41625074 @default.
- W2950393634 hasConceptScore W2950393634C47701112 @default.
- W2950393634 hasConceptScore W2950393634C515207424 @default.
- W2950393634 hasConceptScore W2950393634C55493867 @default.
- W2950393634 hasConceptScore W2950393634C70721500 @default.
- W2950393634 hasConceptScore W2950393634C86803240 @default.
- W2950393634 hasLocation W29503936341 @default.
- W2950393634 hasLocation W29503936342 @default.
- W2950393634 hasLocation W29503936343 @default.
- W2950393634 hasOpenAccess W2950393634 @default.
- W2950393634 hasPrimaryLocation W29503936341 @default.
- W2950393634 hasRelatedWork W1971026764 @default.
- W2950393634 hasRelatedWork W2062760462 @default.
- W2950393634 hasRelatedWork W2067048055 @default.
- W2950393634 hasRelatedWork W2074924536 @default.
- W2950393634 hasRelatedWork W2080154871 @default.
- W2950393634 hasRelatedWork W2111487581 @default.
- W2950393634 hasRelatedWork W2290103266 @default.
- W2950393634 hasRelatedWork W2953341326 @default.
- W2950393634 hasRelatedWork W4298042739 @default.
- W2950393634 hasRelatedWork W4385294891 @default.
- W2950393634 isParatext "false" @default.
- W2950393634 isRetracted "false" @default.
- W2950393634 magId "2950393634" @default.
- W2950393634 workType "article" @default.