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• W2950397789 abstract "BackgroundSeveral studies have described a worse prognosis for right-sided colon cancer compared to left-sided. The aim of this study was to compare patterns of recurrence and survival following resection of liver metastases (LM) from right-sided (RS) versus left-sided (LS) colon cancer.MethodsPatients undergoing resection for colon cancer LM between 2000 and 2017 were analyzed. Rectal cancer, multiple primaries and unknown location were excluded.ResultsOut of 995 patients, 686 fulfilled inclusion criteria (RS-LM = 322, LS-LM = 364). RS colon cancer had higher prevalence of metastatic lymph nodes (67.4% vs. 57.1%, P = 0.008). RS-LM were more often mucinous (16.8% vs. 8.5%, P = 0.001) and G3 (58.3% vs. 48.9%, P = 0.014). 451 (65.7%) patients experienced recurrence (RS-LM 68.9% vs. LS-LM 62.9%). In RS-LM group, recurrence was more often encephalic (2.3% vs. 0%, P = 0.029) and at multiple sites (34.2% vs. 23.5%, P = 0.012). The rate of re-resection was lower in RS-LM patients (27.9% vs. 37.5%, P = 0.024). Multivariate analysis showed RS-LM to have worse 5-year overall (35.8% vs. 51.2%, P = 0.002) and disease-free survival (26% vs. 43.6%, P = 0.002).ConclusionsRS-LM is associated with worse survival and aggressive recurrences, with lower chance of re-resection." @default.
• W2950397789 created "2019-06-27" @default.
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• W2950397789 date "2020-01-01" @default.
• W2950397789 modified "2023-10-13" @default.
• W2950397789 title "Impact of primary tumor location on patterns of recurrence and survival of patients undergoing resection of liver metastases from colon cancer" @default.
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• W2950397789 doi "https://doi.org/10.1016/j.hpb.2019.05.014" @default.
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