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• W2950434359 abstract "Abstract In the rod-shaped bacterium Escherichia coli , the actin-like protein MreB localizes in a curvature-dependent manner and spatially coordinates cell-wall insertion to maintain cell shape across changing environments, although the molecular mechanism by which cell width is regulated remains unknown. Here, we demonstrate that the bitopic membrane protein RodZ regulates the biophysical properties of MreB and alters the spatial organization of E. coli cell-wall growth. The relative expression levels of MreB and RodZ changed in a manner commensurate with variations in growth rate and cell width. We carried out single-cell analyses to determine that RodZ systematically alters the curvature-based localization of MreB and cell width in a manner dependent on the concentration of RodZ. Finally, we identified MreB mutants that we predict using molecular dynamics simulations to alter the bending properties of MreB filaments at the molecular scale similar to RodZ binding, and showed that these mutants rescued rod-like shape in the absence of RodZ alone or in combination with wild-type MreB. Together, our results show that E. coli controls its shape and dimensions by differentially regulating RodZ and MreB to alter the patterning of cell-wall insertion, highlighting the rich regulatory landscape of cytoskeletal molecular biophysics." @default.
• W2950434359 created "2019-06-27" @default.
• W2950434359 creator A5020536779 @default.
• W2950434359 creator A5052019253 @default.
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• W2950434359 date "2017-12-04" @default.
• W2950434359 modified "2023-09-27" @default.
• W2950434359 title "RodZ modulates geometric localization of the bacterial actin MreB to regulate cell shape" @default.
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• W2950434359 doi "https://doi.org/10.1101/229286" @default.
• W2950434359 hasPublicationYear "2017" @default.
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