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• W2950442776 endingPage "909" @default.
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• W2950442776 abstract "To enhance the chemotherapy effect to MDA-MB-231, a glutathione (GSH)-sensitive amphiphilic hyperbranched poly (amide-amine) (mPEG-PLGA-HPAA) was synthesized, and the anti-cancer drug, paclitaxel (PTX) was then encapsulated into the mPEG-PLGA-HPAA micelles. The mPEG-PLGA-HPAA containing a large number of disulfide bonds could degrade and then consume the GSH intracellularly, which was expected to enhances the sensitivity of MDA-MB-231 cells to PTX. It was found that the mPEG-PLGA-HPAA/PTX nanoparticles could respond to the GSH and showed a GSH-controlled PTX release. Simultaneously, the mPEG-PLGA-HPAA/PTX nanoparticles significantly enhanced the efficacy of PTX by inhibiting MDA-MB-231 cells proliferation and inducing cells apoptosis, performing the self-sensitization effect of chemotherapy. Moreover, the drug carrier of mPEG-PLGA-HPAA exhibited excellent biocompatibility in vitro and in vivo. These results indicated that the self-sensitized drug carrier is a promising route to maximize the therapeutic effect and minimize the side effects of chemotherapy drugs used currently in clinical." @default.
• W2950442776 created "2019-06-27" @default.
• W2950442776 creator A5001877165 @default.
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• W2950442776 date "2019-09-01" @default.
• W2950442776 modified "2023-10-05" @default.
• W2950442776 title "A chemotherapeutic self-sensibilized drug carrier delivering paclitaxel for the enhanced chemotherapy to human breast MDA-MB-231 cells" @default.
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• W2950442776 doi "https://doi.org/10.1016/j.colsurfb.2019.06.052" @default.
• W2950442776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31382339" @default.
• W2950442776 hasPublicationYear "2019" @default.
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