Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950445981> ?p ?o ?g. }
- W2950445981 endingPage "1307" @default.
- W2950445981 startingPage "1298" @default.
- W2950445981 abstract "The conformations accessible to proteins are determined by the inter-residue interactions between amino acid residues. During evolution, structural constraints that are required for protein function providing biologically relevant information can exist. Here, we studied the proportion of sites evolving under structural constraints in two very different types of ensembles, those coming from ordered and disordered proteins. Using a structurally constrained model of protein evolution, we found that both types of ensembles show comparable, near 40%, number of positions evolving under structural constraints. Among these sites, ~68% are in disordered regions and ~57% of them show long-range inter-residue contacts. Also, we found that disordered ensembles are redundant in reference to their structurally constrained evolutionary information and could be described on average with ~11 conformers. Despite the different complexity of the studied ensembles and proteins, the similar constraints reveal a comparable level of selective pressure to maintain their biological functions. These results highlight the importance of the evolutionary information to recover meaningful biological information to further characterize conformational ensembles." @default.
- W2950445981 created "2019-06-27" @default.
- W2950445981 creator A5010536481 @default.
- W2950445981 creator A5023085479 @default.
- W2950445981 creator A5061169523 @default.
- W2950445981 creator A5066560665 @default.
- W2950445981 creator A5087702932 @default.
- W2950445981 date "2019-03-01" @default.
- W2950445981 modified "2023-10-07" @default.
- W2950445981 title "Ensembles from Ordered and Disordered Proteins Reveal Similar Structural Constraints during Evolution" @default.
- W2950445981 cites W1511973158 @default.
- W2950445981 cites W1772256520 @default.
- W2950445981 cites W1964439982 @default.
- W2950445981 cites W1969148830 @default.
- W2950445981 cites W1970040698 @default.
- W2950445981 cites W1970074020 @default.
- W2950445981 cites W1991804333 @default.
- W2950445981 cites W1995172756 @default.
- W2950445981 cites W2006964552 @default.
- W2950445981 cites W2008545402 @default.
- W2950445981 cites W2009435671 @default.
- W2950445981 cites W2013354180 @default.
- W2950445981 cites W2019869167 @default.
- W2950445981 cites W2038972833 @default.
- W2950445981 cites W2044114335 @default.
- W2950445981 cites W2052962917 @default.
- W2950445981 cites W2062018285 @default.
- W2950445981 cites W2065385636 @default.
- W2950445981 cites W2071052780 @default.
- W2950445981 cites W2076249828 @default.
- W2950445981 cites W2077745997 @default.
- W2950445981 cites W2086091776 @default.
- W2950445981 cites W2091326717 @default.
- W2950445981 cites W2096619551 @default.
- W2950445981 cites W2097270746 @default.
- W2950445981 cites W2101052277 @default.
- W2950445981 cites W2105254477 @default.
- W2950445981 cites W2107867854 @default.
- W2950445981 cites W2113030357 @default.
- W2950445981 cites W2116146706 @default.
- W2950445981 cites W2117161143 @default.
- W2950445981 cites W2120836664 @default.
- W2950445981 cites W2134742468 @default.
- W2950445981 cites W2138178197 @default.
- W2950445981 cites W2142378715 @default.
- W2950445981 cites W2142635246 @default.
- W2950445981 cites W2144901174 @default.
- W2950445981 cites W2149472608 @default.
- W2950445981 cites W2154131901 @default.
- W2950445981 cites W2154414334 @default.
- W2950445981 cites W2156465034 @default.
- W2950445981 cites W2159275700 @default.
- W2950445981 cites W2159985140 @default.
- W2950445981 cites W2171371127 @default.
- W2950445981 cites W2171912054 @default.
- W2950445981 cites W2253998456 @default.
- W2950445981 cites W2265800909 @default.
- W2950445981 cites W2266439690 @default.
- W2950445981 cites W2275524693 @default.
- W2950445981 cites W2315174892 @default.
- W2950445981 cites W2326502613 @default.
- W2950445981 cites W2395425574 @default.
- W2950445981 cites W2425595198 @default.
- W2950445981 cites W2536382347 @default.
- W2950445981 cites W2588882032 @default.
- W2950445981 cites W2591756625 @default.
- W2950445981 cites W2600349519 @default.
- W2950445981 cites W2603131170 @default.
- W2950445981 cites W2755392164 @default.
- W2950445981 cites W2898310021 @default.
- W2950445981 cites W2949760854 @default.
- W2950445981 cites W2951524055 @default.
- W2950445981 cites W4210968583 @default.
- W2950445981 cites W4255594044 @default.
- W2950445981 doi "https://doi.org/10.1016/j.jmb.2019.01.031" @default.
- W2950445981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30731089" @default.
- W2950445981 hasPublicationYear "2019" @default.
- W2950445981 type Work @default.
- W2950445981 sameAs 2950445981 @default.
- W2950445981 citedByCount "8" @default.
- W2950445981 countsByYear W29504459812019 @default.
- W2950445981 countsByYear W29504459812020 @default.
- W2950445981 countsByYear W29504459812021 @default.
- W2950445981 countsByYear W29504459812022 @default.
- W2950445981 crossrefType "journal-article" @default.
- W2950445981 hasAuthorship W2950445981A5010536481 @default.
- W2950445981 hasAuthorship W2950445981A5023085479 @default.
- W2950445981 hasAuthorship W2950445981A5061169523 @default.
- W2950445981 hasAuthorship W2950445981A5066560665 @default.
- W2950445981 hasAuthorship W2950445981A5087702932 @default.
- W2950445981 hasBestOaLocation W29504459812 @default.
- W2950445981 hasConcept C104317684 @default.
- W2950445981 hasConcept C167625842 @default.
- W2950445981 hasConcept C185592680 @default.
- W2950445981 hasConcept C186060115 @default.
- W2950445981 hasConcept C2777936996 @default.
- W2950445981 hasConcept C2986374874 @default.
- W2950445981 hasConcept C2992240565 @default.