Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950454890> ?p ?o ?g. }
- W2950454890 abstract "Summary N -Methyl-D-aspartate receptors (NMDARs) play essential roles in memory formation, neuronal plasticity and brain development with their dysfunction linked to a range of disorders from ischemia to schizophrenia. Zinc and pH are physiological allosteric modulators of NMDARs with GluN2A containing receptors inhibited by nanomolar concentrations of divalent zinc and by excursions to low pH. Despite the widespread importance of zinc and proton modulation of NMDARs, the molecular mechanism by which these ions modulate receptor activity has proven elusive. Here, we use cryo-electron microscopy to elucidate the structure of the GluN1/GluN2A NMDAR in a large ensemble of conformations under a range of physiologically relevant zinc and proton concentrations. We show how zinc binding to the amino terminal domain elicits structural changes that are transduced though the ligand-binding domain and result in constriction of the ion channel gate." @default.
- W2950454890 created "2019-06-27" @default.
- W2950454890 creator A5013854148 @default.
- W2950454890 creator A5014528431 @default.
- W2950454890 creator A5062831188 @default.
- W2950454890 creator A5088125571 @default.
- W2950454890 date "2018-07-26" @default.
- W2950454890 modified "2023-09-30" @default.
- W2950454890 title "Mechanisms for zinc and proton inhibition of the GluN1/GluN2A NMDA receptor" @default.
- W2950454890 cites W1523646668 @default.
- W2950454890 cites W1656913045 @default.
- W2950454890 cites W1918304474 @default.
- W2950454890 cites W1966515122 @default.
- W2950454890 cites W1966517040 @default.
- W2950454890 cites W1969298446 @default.
- W2950454890 cites W1972834856 @default.
- W2950454890 cites W1991588013 @default.
- W2950454890 cites W1996586859 @default.
- W2950454890 cites W1997568797 @default.
- W2950454890 cites W2000300989 @default.
- W2950454890 cites W2003701228 @default.
- W2950454890 cites W2011265174 @default.
- W2950454890 cites W2012641732 @default.
- W2950454890 cites W2019357760 @default.
- W2950454890 cites W2020265449 @default.
- W2950454890 cites W2024380057 @default.
- W2950454890 cites W2028470175 @default.
- W2950454890 cites W2036729022 @default.
- W2950454890 cites W2037852973 @default.
- W2950454890 cites W2044958998 @default.
- W2950454890 cites W2046203683 @default.
- W2950454890 cites W2051909860 @default.
- W2950454890 cites W2060893933 @default.
- W2950454890 cites W2061108756 @default.
- W2950454890 cites W2075824676 @default.
- W2950454890 cites W2086487208 @default.
- W2950454890 cites W2089094370 @default.
- W2950454890 cites W2090166619 @default.
- W2950454890 cites W2092220359 @default.
- W2950454890 cites W2104234755 @default.
- W2950454890 cites W2111228774 @default.
- W2950454890 cites W2116696802 @default.
- W2950454890 cites W2122595342 @default.
- W2950454890 cites W2132629607 @default.
- W2950454890 cites W2142161929 @default.
- W2950454890 cites W2144081223 @default.
- W2950454890 cites W2152301430 @default.
- W2950454890 cites W2158359318 @default.
- W2950454890 cites W2159389717 @default.
- W2950454890 cites W2159976043 @default.
- W2950454890 cites W2162454135 @default.
- W2950454890 cites W2180229411 @default.
- W2950454890 cites W2276585871 @default.
- W2950454890 cites W2319385595 @default.
- W2950454890 cites W2343219805 @default.
- W2950454890 cites W2418457293 @default.
- W2950454890 cites W2467790803 @default.
- W2950454890 cites W2519747458 @default.
- W2950454890 cites W2558403885 @default.
- W2950454890 cites W2559974546 @default.
- W2950454890 cites W2587625522 @default.
- W2950454890 cites W2590999072 @default.
- W2950454890 cites W2593511418 @default.
- W2950454890 cites W2606915259 @default.
- W2950454890 cites W2763663585 @default.
- W2950454890 cites W2791354025 @default.
- W2950454890 cites W2797071919 @default.
- W2950454890 cites W2950967305 @default.
- W2950454890 doi "https://doi.org/10.1101/378422" @default.
- W2950454890 hasPublicationYear "2018" @default.
- W2950454890 type Work @default.
- W2950454890 sameAs 2950454890 @default.
- W2950454890 citedByCount "0" @default.
- W2950454890 crossrefType "posted-content" @default.
- W2950454890 hasAuthorship W2950454890A5013854148 @default.
- W2950454890 hasAuthorship W2950454890A5014528431 @default.
- W2950454890 hasAuthorship W2950454890A5062831188 @default.
- W2950454890 hasAuthorship W2950454890A5088125571 @default.
- W2950454890 hasBestOaLocation W29504548901 @default.
- W2950454890 hasConcept C104317684 @default.
- W2950454890 hasConcept C12554922 @default.
- W2950454890 hasConcept C166342909 @default.
- W2950454890 hasConcept C169760540 @default.
- W2950454890 hasConcept C170493617 @default.
- W2950454890 hasConcept C178790620 @default.
- W2950454890 hasConcept C185592680 @default.
- W2950454890 hasConcept C24284526 @default.
- W2950454890 hasConcept C50254741 @default.
- W2950454890 hasConcept C535196362 @default.
- W2950454890 hasConcept C55493867 @default.
- W2950454890 hasConcept C61174792 @default.
- W2950454890 hasConcept C67018056 @default.
- W2950454890 hasConcept C82617044 @default.
- W2950454890 hasConcept C86339819 @default.
- W2950454890 hasConcept C86803240 @default.
- W2950454890 hasConceptScore W2950454890C104317684 @default.
- W2950454890 hasConceptScore W2950454890C12554922 @default.
- W2950454890 hasConceptScore W2950454890C166342909 @default.
- W2950454890 hasConceptScore W2950454890C169760540 @default.
- W2950454890 hasConceptScore W2950454890C170493617 @default.