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- W2950456145 abstract "We present a theoretical model for retinocollicular map development, which can account for intriguing behaviors observed in gain-of-function experiments in knock-in mice by Brown et al., including bifurcation in heterozygous Isl2/EphA3 knock-ins. The model is based on known chemical labels, axonal repulsion/competition, stochasticity and uses Markov chain description. Our model suggests that the map in heterozygotes is single-valued in the temporal region of retina due to reduced gradient of ephrin in the corresponding region of SC. The remaining map is double-valued since the gradient of ephrin is high there. We predict therefore that if gradient of ephrin is reduced by a genetic manipulation, the single-valued region of the map should occupy a larger portion of temporal retina, i.e. the point of transition between single- and doulble-valued maps should move to a more nasal position in Isl2-EphA3 heterozygotes. We also discuss the importance of inhomogeneous EphA gradient and mapping in Isl2/EphB knock-ins." @default.
- W2950456145 created "2019-06-27" @default.
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- W2950456145 date "2003-07-22" @default.
- W2950456145 modified "2023-09-27" @default.
- W2950456145 title "A stochastic model for retinocollicular map development" @default.
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