FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950456282> ?p ?o ?g. }

• W2950456282 endingPage "3239" @default.
• W2950456282 startingPage "3229" @default.
• W2950456282 abstract "Juvenile myelomonocytic leukemia (JMML) is an invasive myeloproliferative neoplasm and is a childhood disease with very high clinical lethality. The SHP2 is encoded by the PTPN11 gene, which is a nonreceptor (pY)-phosphatase and mutation causes JMML. The structural hierarchy of SHP2 includes protein tyrosine phosphatase domain (PTP) and Src-homology 2 domain (N-SH2 and C-SH2). Somatic mutation (E76Q) in the interface of SH2-PTP domain is the most commonly identified mutation found in up to 35% of patients with JMML. The mechanism of this mutant associated with JMML is poorly understood. Here, molecular dynamics simulation was performed on wild-type and mutant (E76Q) of SHP2 to explore the precise impact of gain-of-function on PTP's activity. Consequently, such impact rescues the SHP2 protein from autoinhibition state through losing the interface interactions of Q256/F7 and S502/Q76 or weakening interactions of Q256/R4, Q510/G60, and Q506/A72 between N-SH2 and PTP domains. The consequences of these interactions further relieve the D'E loop away from the PTP catalytic site. The following study would provide a mechanistic insight for better understanding of how individual SHP2 mutations alter the PTP's activity at the atomic level." @default.
• W2950456282 created "2019-06-27" @default.
• W2950456282 creator A5001104778 @default.
• W2950456282 creator A5052148205 @default.
• W2950456282 creator A5054717479 @default.
• W2950456282 creator A5061318449 @default.
• W2950456282 creator A5078672013 @default.
• W2950456282 creator A5080048995 @default.
• W2950456282 creator A5080209274 @default.
• W2950456282 creator A5086992948 @default.
• W2950456282 creator A5088664989 @default.
• W2950456282 date "2019-06-20" @default.
• W2950456282 modified "2023-10-16" @default.
• W2950456282 title "Gain-of-Function SHP2 E76Q Mutant Rescuing Autoinhibition Mechanism Associated with Juvenile Myelomonocytic Leukemia" @default.
• W2950456282 cites W1488372279 @default.
• W2950456282 cites W1536598892 @default.
• W2950456282 cites W1969046853 @default.
• W2950456282 cites W1975580333 @default.
• W2950456282 cites W1987983260 @default.
• W2950456282 cites W2019189533 @default.
• W2950456282 cites W2023090301 @default.
• W2950456282 cites W2035090874 @default.
• W2950456282 cites W2043160859 @default.
• W2950456282 cites W2043245988 @default.
• W2950456282 cites W2054938865 @default.
• W2950456282 cites W2058398046 @default.
• W2950456282 cites W2059338259 @default.
• W2950456282 cites W2061122212 @default.
• W2950456282 cites W2062105576 @default.
• W2950456282 cites W2066932792 @default.
• W2950456282 cites W2067174909 @default.
• W2950456282 cites W2069098917 @default.
• W2950456282 cites W2091439890 @default.
• W2950456282 cites W2094548766 @default.
• W2950456282 cites W2099246483 @default.
• W2950456282 cites W2104919283 @default.
• W2950456282 cites W2106140689 @default.
• W2950456282 cites W2130526419 @default.
• W2950456282 cites W2132525235 @default.
• W2950456282 cites W2138480068 @default.
• W2950456282 cites W2161605421 @default.
• W2950456282 cites W2313116527 @default.
• W2950456282 cites W2317996983 @default.
• W2950456282 cites W2414728798 @default.
• W2950456282 cites W2468923062 @default.
• W2950456282 cites W2599273944 @default.
• W2950456282 cites W2692515715 @default.
• W2950456282 cites W2767972593 @default.
• W2950456282 cites W2781625157 @default.
• W2950456282 cites W2899222565 @default.
• W2950456282 cites W2900434387 @default.
• W2950456282 cites W2914497263 @default.
• W2950456282 cites W2918131915 @default.
• W2950456282 doi "https://doi.org/10.1021/acs.jcim.9b00353" @default.
• W2950456282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31244092" @default.
• W2950456282 hasPublicationYear "2019" @default.
• W2950456282 type Work @default.
• W2950456282 sameAs 2950456282 @default.
• W2950456282 citedByCount "34" @default.
• W2950456282 countsByYear W29504562822019 @default.
• W2950456282 countsByYear W29504562822020 @default.
• W2950456282 countsByYear W29504562822021 @default.
• W2950456282 countsByYear W29504562822022 @default.
• W2950456282 countsByYear W29504562822023 @default.
• W2950456282 crossrefType "journal-article" @default.
• W2950456282 hasAuthorship W2950456282A5001104778 @default.
• W2950456282 hasAuthorship W2950456282A5052148205 @default.
• W2950456282 hasAuthorship W2950456282A5054717479 @default.
• W2950456282 hasAuthorship W2950456282A5061318449 @default.
• W2950456282 hasAuthorship W2950456282A5078672013 @default.
• W2950456282 hasAuthorship W2950456282A5080048995 @default.
• W2950456282 hasAuthorship W2950456282A5080209274 @default.
• W2950456282 hasAuthorship W2950456282A5086992948 @default.
• W2950456282 hasAuthorship W2950456282A5088664989 @default.
• W2950456282 hasConcept C104317684 @default.
• W2950456282 hasConcept C108636557 @default.
• W2950456282 hasConcept C109159458 @default.
• W2950456282 hasConcept C11960822 @default.
• W2950456282 hasConcept C13514818 @default.
• W2950456282 hasConcept C143065580 @default.
• W2950456282 hasConcept C2779157977 @default.
• W2950456282 hasConcept C2781187634 @default.
• W2950456282 hasConcept C28328180 @default.
• W2950456282 hasConcept C3020204279 @default.
• W2950456282 hasConcept C31734879 @default.
• W2950456282 hasConcept C501734568 @default.
• W2950456282 hasConcept C502942594 @default.
• W2950456282 hasConcept C54355233 @default.
• W2950456282 hasConcept C85528070 @default.
• W2950456282 hasConcept C86803240 @default.
• W2950456282 hasConceptScore W2950456282C104317684 @default.
• W2950456282 hasConceptScore W2950456282C108636557 @default.
• W2950456282 hasConceptScore W2950456282C109159458 @default.
• W2950456282 hasConceptScore W2950456282C11960822 @default.
• W2950456282 hasConceptScore W2950456282C13514818 @default.
• W2950456282 hasConceptScore W2950456282C143065580 @default.
• W2950456282 hasConceptScore W2950456282C2779157977 @default.
• W2950456282 hasConceptScore W2950456282C2781187634 @default.

• next