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• W2950463528 abstract "Gene trees can differ from species trees due to a variety of biological phenomena, the most prevalent being gene duplication, horizontal gene transfer, gene loss, and coalescence. To explain topological incongruence between the two trees, researchers apply reconciliation methods, often relying on a maximum parsimony framework. However, while several studies have investigated the space of maximum parsimony reconciliations (MPRs) under the duplication-loss and duplication-transfer-loss models, the space of MPRs under the duplication-loss-coalescence (DLC) model remains poorly understood. To address this problem, we present new algorithms for computing the size of MPR space under the DLC model and sampling from this space uniformly at random. Our algorithms are efficient in practice, with runtime polynomial in the size of the species and gene tree when the number of genes that map to any given species is fixed, thus proving that the MPR problem is fixed-parameter tractable. We have applied our methods to a biological data set of 16 fungal species to provide the first key insights in the space of MPRs under the DLC model. Our results show that a plurality reconciliation, and underlying events, are likely to be representative of MPR space." @default.
• W2950463528 created "2019-06-27" @default.
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• W2950463528 date "2021-11-01" @default.
• W2950463528 modified "2023-10-14" @default.
• W2950463528 title "Multiple Optimal Reconciliations Under the Duplication-Loss-Coalescence Model" @default.
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• W2950463528 doi "https://doi.org/10.1109/tcbb.2019.2922337" @default.
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• W2950463528 hasPublicationYear "2021" @default.
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