FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950463539> ?p ?o ?g. }

• W2950463539 endingPage "12399" @default.
• W2950463539 startingPage "12390" @default.
• W2950463539 abstract "Long-range gene regulation involves physical proximity between enhancers and promoters to generate precise patterns of gene expression in space and time. However, in some cases, proximity coincides with gene activation, whereas, in others, preformed topologies already exist before activation. In this study, we investigate the preformed configuration underlying the regulation of the Shh gene by its unique limb enhancer, the ZRS , in vivo during mouse development. Abrogating the constitutive transcription covering the ZRS region led to a shift within the Shh–ZRS contacts and a moderate reduction in Shh transcription. Deletion of the CTCF binding sites around the ZRS resulted in the loss of the Shh–ZRS preformed interaction and a 50% decrease in Shh expression but no phenotype, suggesting an additional, CTCF-independent mechanism of promoter–enhancer communication. This residual activity, however, was diminished by combining the loss of CTCF binding with a hypomorphic ZRS allele, resulting in severe Shh loss of function and digit agenesis. Our results indicate that the preformed chromatin structure of the Shh locus is sustained by multiple components and acts to reinforce enhancer–promoter communication for robust transcription." @default.
• W2950463539 created "2019-06-27" @default.
• W2950463539 creator A5001301955 @default.
• W2950463539 creator A5009628707 @default.
• W2950463539 creator A5019743657 @default.
• W2950463539 creator A5021773558 @default.
• W2950463539 creator A5023743496 @default.
• W2950463539 creator A5027763337 @default.
• W2950463539 creator A5034123513 @default.
• W2950463539 creator A5034850910 @default.
• W2950463539 creator A5043110549 @default.
• W2950463539 creator A5044366692 @default.
• W2950463539 creator A5046072249 @default.
• W2950463539 creator A5047272346 @default.
• W2950463539 creator A5051350129 @default.
• W2950463539 creator A5058085500 @default.
• W2950463539 creator A5067697026 @default.
• W2950463539 creator A5087454836 @default.
• W2950463539 creator A5088054119 @default.
• W2950463539 creator A5090553213 @default.
• W2950463539 date "2019-05-30" @default.
• W2950463539 modified "2023-10-16" @default.
• W2950463539 title "Preformed chromatin topology assists transcriptional robustness of <i>Shh</i> during limb development" @default.
• W2950463539 cites W1531821806 @default.
• W2950463539 cites W1831401007 @default.
• W2950463539 cites W1960015501 @default.
• W2950463539 cites W1966503939 @default.
• W2950463539 cites W1970831058 @default.
• W2950463539 cites W1973062929 @default.
• W2950463539 cites W1975542854 @default.
• W2950463539 cites W1991149014 @default.
• W2950463539 cites W2002391499 @default.
• W2950463539 cites W2008227324 @default.
• W2950463539 cites W2030346902 @default.
• W2950463539 cites W2036897871 @default.
• W2950463539 cites W2052714727 @default.
• W2950463539 cites W2067585563 @default.
• W2950463539 cites W2070021921 @default.
• W2950463539 cites W2074324848 @default.
• W2950463539 cites W2080477348 @default.
• W2950463539 cites W2089894746 @default.
• W2950463539 cites W2091548199 @default.
• W2950463539 cites W2098497185 @default.
• W2950463539 cites W2099034339 @default.
• W2950463539 cites W2102368172 @default.
• W2950463539 cites W2103441770 @default.
• W2950463539 cites W2107277218 @default.
• W2950463539 cites W2132117628 @default.
• W2950463539 cites W2134907628 @default.
• W2950463539 cites W2145144631 @default.
• W2950463539 cites W2158919523 @default.
• W2950463539 cites W2160856280 @default.
• W2950463539 cites W2161212572 @default.
• W2950463539 cites W2166278566 @default.
• W2950463539 cites W2167778259 @default.
• W2950463539 cites W2170551349 @default.
• W2950463539 cites W2170723451 @default.
• W2950463539 cites W2192080449 @default.
• W2950463539 cites W2259938310 @default.
• W2950463539 cites W2269163732 @default.
• W2950463539 cites W2341539131 @default.
• W2950463539 cites W2401568148 @default.
• W2950463539 cites W2414714080 @default.
• W2950463539 cites W2470258573 @default.
• W2950463539 cites W2481029670 @default.
• W2950463539 cites W2523349158 @default.
• W2950463539 cites W2528263447 @default.
• W2950463539 cites W2536097271 @default.
• W2950463539 cites W2559911833 @default.
• W2950463539 cites W2575997426 @default.
• W2950463539 cites W2577253766 @default.
• W2950463539 cites W2594685900 @default.
• W2950463539 cites W2602710346 @default.
• W2950463539 cites W2609923598 @default.
• W2950463539 cites W2614144400 @default.
• W2950463539 cites W262549320 @default.
• W2950463539 cites W2734750512 @default.
• W2950463539 cites W2746882347 @default.
• W2950463539 cites W2757387674 @default.
• W2950463539 cites W2761461280 @default.
• W2950463539 cites W2765567136 @default.
• W2950463539 cites W2767826728 @default.
• W2950463539 cites W2795649462 @default.
• W2950463539 cites W2797715364 @default.
• W2950463539 cites W2888200508 @default.
• W2950463539 cites W2890753820 @default.
• W2950463539 cites W2894289085 @default.
• W2950463539 cites W2898514070 @default.
• W2950463539 cites W2953029843 @default.
• W2950463539 doi "https://doi.org/10.1073/pnas.1900672116" @default.
• W2950463539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6589666" @default.
• W2950463539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31147463" @default.
• W2950463539 hasPublicationYear "2019" @default.
• W2950463539 type Work @default.
• W2950463539 sameAs 2950463539 @default.
• W2950463539 citedByCount "119" @default.
• W2950463539 countsByYear W29504635392019 @default.
• W2950463539 countsByYear W29504635392020 @default.

• next