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- W2950463963 abstract "Viral single-stranded (ss) RNA is the natural ligand for TLR7 and TLR8. Synthetic ssRNA has been shown to act as a ligand for TLR7 and TLR8. We have previously reported a novel RNA structure, referred to as stabilized immune modulatory RNA (SIMRA), in which two short phosphorothioate oligoribonucleotides were linked through their 3'-ends via a linker. SIMRA compounds had greater stability in serum than unmodified ssRNA and induced immune responses via TLR7 and/or TLR8. SIMRA compounds were synthesized using phosphoramidite chemistry on controlled-pore glass solid support derivatized with a linker. After cleavage from the solid support and removal of protecting groups, SIMRA compounds were purified on an anion-exchange HPLC followed by desalting/dialysis, and lyophilization. SIMRA compounds were characterized for their purity and sequence integrity by anion-exchange HPLC, capillary gel electrophoresis, polyacrylamide gel electrophoresis, and MALDI-TOF mass spectrophotometric analysis. As SIMRA compounds induce TLR7- and/or TLR8-mediated Th1-type immune responses, they have potential utility as therapeutic agents for a broad range of diseases, including cancer, infectious diseases, asthma, and allergies, and as adjuvants with vaccines." @default.
- W2950463963 created "2019-06-27" @default.
- W2950463963 creator A5038151859 @default.
- W2950463963 creator A5088791437 @default.
- W2950463963 date "2012-08-09" @default.
- W2950463963 modified "2023-09-27" @default.
- W2950463963 title "ChemInform Abstract: Synthesis, Purification, and Characterization of Oligoribonucleotides That Act as Agonists of TLR7 and/or TLR8" @default.
- W2950463963 cites W2466289720 @default.
- W2950463963 doi "https://doi.org/10.1002/chin.201236249" @default.
- W2950463963 hasPublicationYear "2012" @default.
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