FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950470226> ?p ?o ?g. }

• W2950470226 abstract "Abstract Although previous studies have identified many extracellular guidance molecules and intracellular signaling proteins that regulate axonal outgrowth and extension, most were conducted in the context of unidirectional neurite growth, in which the guidance cues either attract or repel growth cones. Very few studies addressed how intracellular signaling molecules differentially specify bidirectional outgrowth. Here, using the bipolar PLM neurons in C. elegans , we show that the guanine nucleotide exchange factors (GEFs) UNC-73/Trio and TIAM-1 promote anterior and posterior neurite extension, respectively. The Rac subfamily GTPases act downstream of the GEFs; CED-10/Rac1 is activated by TIAM-1, whereas CED-10 and MIG-2/RhoG act redundantly downstream of UNC-73. Moreover, these two pathways antagonize each other and, thus, regulate the directional bias of neuritogenesis. Our study suggests that directional specificity of neurite extension is conferred through the intracellular activation of distinct GEFs and Rac GTPases. Significance Statement Most previous studies on intracellular signaling during neurite guidance were performed in the context of unidirectional neurite growth. They could not address the molecular basis of directional outgrowth of multiple neurites mainly because of the lack of a good model system. Using a pair of bipolar neurons in the nematode Caenorhabditis elegans , we found that distinct sets of intracellular molecules are required for neurite extension towards the anterior and the posterior. Moreover, signaling pathways that promote neurite extension in different directions antagonize each other to achieve balanced growth. Therefore, our study offers an in vivo example for a long-standing concept that spatially selective activation of intracellular signaling molecules could enable a diverse range of neuronal growth patterns." @default.
• W2950470226 created "2019-06-27" @default.
• W2950470226 creator A5001174578 @default.
• W2950470226 creator A5002528916 @default.
• W2950470226 creator A5074638214 @default.
• W2950470226 date "2016-05-06" @default.
• W2950470226 modified "2023-10-17" @default.
• W2950470226 title "GEFs and Rac GTPases control directional specificity of neurite extension along the anterior-posterior axis" @default.
• W2950470226 cites W139516685 @default.
• W2950470226 cites W1523918896 @default.
• W2950470226 cites W1535253637 @default.
• W2950470226 cites W1667125033 @default.
• W2950470226 cites W1781370777 @default.
• W2950470226 cites W1905036343 @default.
• W2950470226 cites W1984387240 @default.
• W2950470226 cites W1989184804 @default.
• W2950470226 cites W1989957067 @default.
• W2950470226 cites W1990408088 @default.
• W2950470226 cites W1992557615 @default.
• W2950470226 cites W1993837490 @default.
• W2950470226 cites W1996782310 @default.
• W2950470226 cites W1999832936 @default.
• W2950470226 cites W2001670860 @default.
• W2950470226 cites W2008290466 @default.
• W2950470226 cites W2011815143 @default.
• W2950470226 cites W2012782842 @default.
• W2950470226 cites W2012811502 @default.
• W2950470226 cites W2014552373 @default.
• W2950470226 cites W2027919192 @default.
• W2950470226 cites W2034466289 @default.
• W2950470226 cites W2052325297 @default.
• W2950470226 cites W2053912448 @default.
• W2950470226 cites W2060297895 @default.
• W2950470226 cites W2065904518 @default.
• W2950470226 cites W2066123272 @default.
• W2950470226 cites W2073900221 @default.
• W2950470226 cites W2080438773 @default.
• W2950470226 cites W2087168356 @default.
• W2950470226 cites W2090105213 @default.
• W2950470226 cites W2098011724 @default.
• W2950470226 cites W2099731590 @default.
• W2950470226 cites W2103746066 @default.
• W2950470226 cites W2104948489 @default.
• W2950470226 cites W2109067831 @default.
• W2950470226 cites W2114802139 @default.
• W2950470226 cites W2118081365 @default.
• W2950470226 cites W2123913983 @default.
• W2950470226 cites W2127307813 @default.
• W2950470226 cites W2132994523 @default.
• W2950470226 cites W2133903646 @default.
• W2950470226 cites W2135652244 @default.
• W2950470226 cites W2146473598 @default.
• W2950470226 cites W2147917190 @default.
• W2950470226 cites W2148301289 @default.
• W2950470226 cites W2149246707 @default.
• W2950470226 cites W2155154752 @default.
• W2950470226 cites W2156033174 @default.
• W2950470226 cites W2159565935 @default.
• W2950470226 cites W2160262432 @default.
• W2950470226 cites W2161130983 @default.
• W2950470226 cites W2166600563 @default.
• W2950470226 cites W2212322209 @default.
• W2950470226 doi "https://doi.org/10.1101/052019" @default.
• W2950470226 hasPublicationYear "2016" @default.
• W2950470226 type Work @default.
• W2950470226 sameAs 2950470226 @default.
• W2950470226 citedByCount "0" @default.
• W2950470226 crossrefType "posted-content" @default.
• W2950470226 hasAuthorship W2950470226A5001174578 @default.
• W2950470226 hasAuthorship W2950470226A5002528916 @default.
• W2950470226 hasAuthorship W2950470226A5074638214 @default.
• W2950470226 hasBestOaLocation W29504702261 @default.
• W2950470226 hasConcept C113246987 @default.
• W2950470226 hasConcept C126619667 @default.
• W2950470226 hasConcept C135903288 @default.
• W2950470226 hasConcept C151730666 @default.
• W2950470226 hasConcept C169760540 @default.
• W2950470226 hasConcept C202751555 @default.
• W2950470226 hasConcept C207332259 @default.
• W2950470226 hasConcept C2779343474 @default.
• W2950470226 hasConcept C2779530196 @default.
• W2950470226 hasConcept C2779717556 @default.
• W2950470226 hasConcept C2780298669 @default.
• W2950470226 hasConcept C54355233 @default.
• W2950470226 hasConcept C62478195 @default.
• W2950470226 hasConcept C79879829 @default.
• W2950470226 hasConcept C86803240 @default.
• W2950470226 hasConcept C95444343 @default.
• W2950470226 hasConceptScore W2950470226C113246987 @default.
• W2950470226 hasConceptScore W2950470226C126619667 @default.
• W2950470226 hasConceptScore W2950470226C135903288 @default.
• W2950470226 hasConceptScore W2950470226C151730666 @default.
• W2950470226 hasConceptScore W2950470226C169760540 @default.
• W2950470226 hasConceptScore W2950470226C202751555 @default.
• W2950470226 hasConceptScore W2950470226C207332259 @default.
• W2950470226 hasConceptScore W2950470226C2779343474 @default.
• W2950470226 hasConceptScore W2950470226C2779530196 @default.
• W2950470226 hasConceptScore W2950470226C2779717556 @default.
• W2950470226 hasConceptScore W2950470226C2780298669 @default.
• W2950470226 hasConceptScore W2950470226C54355233 @default.

• next