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• W2950470413 abstract "Cytokines are cell-to-cell signaling proteins that play a central role in immune development, pathogen responses, and diseases. Cytokines are highly regulated at the transcriptional level by combinations of transcription factors (TFs) that recruit cofactors and the transcriptional machinery. Here, we mined through three decades of studies to generate a comprehensive database, CytReg, reporting 843 and 647 interactions between TFs and cytokine genes, in human and mouse respectively. By integrating CytReg with other functional datasets, we determined general principles governing the transcriptional regulation of cytokine genes. In particular, we show a correlation between TF connectivity and immune phenotype and disease, we discuss the balance between tissue-specific and pathogen-activated TFs regulating each cytokine gene, and cooperativity and plasticity in cytokine regulation. We also illustrate the use of our database as a blueprint to predict TF-disease associations and identify potential TF-cytokine regulatory axes in autoimmune diseases. Finally, we discuss research biases in cytokine regulation studies, and use CytReg to predict novel interactions based on co-expression and motif analyses which we further validated experimentally. Overall, this resource provides a framework for the rational design of future cytokine gene regulation studies." @default.
• W2950470413 created "2019-06-27" @default.
• W2950470413 creator A5000975308 @default.
• W2950470413 creator A5004229568 @default.
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• W2950470413 creator A5054588125 @default.
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• W2950470413 creator A5061728452 @default.
• W2950470413 creator A5062718875 @default.
• W2950470413 creator A5070658947 @default.
• W2950470413 date "2018-09-03" @default.
• W2950470413 modified "2023-10-18" @default.
• W2950470413 title "Global landscape of mouse and human cytokine transcriptional regulation" @default.
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• W2950470413 doi "https://doi.org/10.1093/nar/gky787" @default.
• W2950470413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6182173" @default.
• W2950470413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30184180" @default.

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