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• W2950478868 abstract "ABSTRACT The influenza A matrix 2 (M2) transmembrane protein facilitates virion release from the infected host cell. In particular, M2 plays a role in the induction of membrane curvature and/or in the scission process whereby the envelope is cut upon virion release. Here we show using coarse-grained computer simulations that various M2 assembly geometries emerge due to an entropic driving force, resulting in compact clusters or linearly extended aggregates as a direct consequence of the lateral membrane stresses. Conditions under which these protein assemblies will cause the lipid membrane to curve are explored and we predict that a critical cluster size is required for this to happen. We go on to demonstrate that under the stress conditions taking place in the cellular membrane as it undergoes large-scale membrane remodeling, the M2 protein will in principle be able to both contribute to curvature induction and sense curvature in order to line up in manifolds where local membrane line tension is high. M2 is found to exhibit linactant behavior in liquid-disordered/liquid-ordered phase-separated lipid mixtures and to be excluded from the liquid-ordered phase, in near-quantitative agreement with experimental observations. Our findings support a role for M2 in membrane remodeling during influenza viral budding both as an inducer and a sensor of membrane curvature, and they suggest a mechanism by which localization of M2 can occur as the virion assembles and releases from the host cell, independent of how the membrane curvature is produced. SIGNIFICANCE STATEMENT For influenza virus to release from the infected host cell, controlled viral budding must finalize with membrane scission of the viral envelope. Curiously, influenza carries its own protein, M2, which can sever the membrane of the constricted budding neck. Here we elucidate the physical mechanism of clustering and spatial localization of the M2 scission proteins through a combined computational and experimental approach. Our results provide fundamental insights into how M2 clustering and localization interplays with membrane curvature, membrane lateral stresses, and lipid bilayer phase behavior during viral budding in order to contribute to virion release." @default.
• W2950478868 created "2019-06-27" @default.
• W2950478868 creator A5022093166 @default.
• W2950478868 creator A5027405538 @default.
• W2950478868 creator A5033906413 @default.
• W2950478868 creator A5088327041 @default.
• W2950478868 date "2018-03-28" @default.
• W2950478868 modified "2023-09-23" @default.
• W2950478868 title "Entropic Forces Drive Clustering and Spatial Localization of Influenza A M2 During Viral Budding" @default.
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• W2950478868 cites W135005601 @default.
• W2950478868 cites W1529759862 @default.
• W2950478868 cites W1538591251 @default.
• W2950478868 cites W1542159434 @default.
• W2950478868 cites W1569853787 @default.
• W2950478868 cites W1581438400 @default.
• W2950478868 cites W1963480384 @default.
• W2950478868 cites W1970763876 @default.
• W2950478868 cites W1976499671 @default.
• W2950478868 cites W1980065528 @default.
• W2950478868 cites W1981513263 @default.
• W2950478868 cites W1982555875 @default.
• W2950478868 cites W1987033415 @default.
• W2950478868 cites W1989188092 @default.
• W2950478868 cites W1989788129 @default.
• W2950478868 cites W1993745463 @default.
• W2950478868 cites W2006689028 @default.
• W2950478868 cites W2007750417 @default.
• W2950478868 cites W2014503023 @default.
• W2950478868 cites W2019465613 @default.
• W2950478868 cites W2022396428 @default.
• W2950478868 cites W2023742017 @default.
• W2950478868 cites W2029667189 @default.
• W2950478868 cites W2029940779 @default.
• W2950478868 cites W2031543706 @default.
• W2950478868 cites W2032145912 @default.
• W2950478868 cites W2037115572 @default.
• W2950478868 cites W2039529522 @default.
• W2950478868 cites W2040438591 @default.
• W2950478868 cites W2040607876 @default.
• W2950478868 cites W2048839675 @default.
• W2950478868 cites W2050503463 @default.
• W2950478868 cites W2051227217 @default.
• W2950478868 cites W2057411883 @default.
• W2950478868 cites W2058930537 @default.
• W2950478868 cites W2059382533 @default.
• W2950478868 cites W2060872117 @default.
• W2950478868 cites W2061789539 @default.
• W2950478868 cites W2063604653 @default.
• W2950478868 cites W2068472577 @default.
• W2950478868 cites W2069243816 @default.
• W2950478868 cites W2069777230 @default.
• W2950478868 cites W2070652409 @default.
• W2950478868 cites W2071412842 @default.
• W2950478868 cites W2079298235 @default.
• W2950478868 cites W2085857906 @default.
• W2950478868 cites W2087737303 @default.
• W2950478868 cites W2093485136 @default.
• W2950478868 cites W2094209540 @default.
• W2950478868 cites W2106217679 @default.
• W2950478868 cites W2106654936 @default.
• W2950478868 cites W2108700551 @default.
• W2950478868 cites W2109154308 @default.
• W2950478868 cites W2117446062 @default.
• W2950478868 cites W2119494556 @default.
• W2950478868 cites W2120518061 @default.
• W2950478868 cites W2134723427 @default.
• W2950478868 cites W2150981663 @default.
• W2950478868 cites W2157786229 @default.
• W2950478868 cites W2172286296 @default.
• W2950478868 cites W2206954826 @default.
• W2950478868 cites W2268478214 @default.
• W2950478868 cites W2296363138 @default.
• W2950478868 cites W2319217905 @default.
• W2950478868 cites W2327828849 @default.
• W2950478868 cites W2328778123 @default.
• W2950478868 cites W2336431892 @default.
• W2950478868 cites W2410369605 @default.
• W2950478868 cites W2440617698 @default.
• W2950478868 cites W2493802071 @default.
• W2950478868 cites W2513860021 @default.
• W2950478868 cites W2534983528 @default.
• W2950478868 cites W2561394287 @default.
• W2950478868 cites W2588474799 @default.
• W2950478868 cites W2599287676 @default.
• W2950478868 cites W2734451627 @default.
• W2950478868 cites W2770725028 @default.
• W2950478868 cites W2810400150 @default.
• W2950478868 cites W3017082821 @default.
• W2950478868 cites W3099229786 @default.
• W2950478868 cites W3103048080 @default.
• W2950478868 cites W3155828254 @default.
• W2950478868 cites W4290802914 @default.
• W2950478868 doi "https://doi.org/10.1101/291120" @default.
• W2950478868 hasPublicationYear "2018" @default.
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