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- W2950482783 abstract "Objective: Serial imaging studies in the general population remain important to evaluate the usefulness of pathophysiologically relevant biomarkers in predicting the progression of left ventricular (LV) remodeling and dysfunction. Here, we assessed in a general population whether these circulating biomarkers at baseline predict longitudinal changes in LV structure and function. Design and method: In 592 participants (mean age, 50.8 years; 51.4% women; 40.5% hypertensive), we derived echocardiographic indexes reflecting LV structure and function at baseline and after 4.7 years. At baseline, we measured alkaline phosphatase (ALP), markers of collagen turnover (PICP, CITP, MMP1) and high-sensitivity cardiac Troponin T (hs-cTnT). We regressed longitudinal changes in LV indexes on baseline biomarker levels and reported standardized effect sizes as a fraction of the standard deviation of LV change. Results: After full adjustment, a decline in LV longitudinal strain (−14.2%) and increase in E/e′ ratio over time (+18.9%; P < 0.019) was associated with higher ALP activity at baseline. Furthermore, LV longitudinal strain decreased with higher levels of collagen I production and degradation at baseline (PICP: −14.2%, CITP: −16.4%; P < 0.029). An increase in E/e′ ratio over time was borderline associated with lower MMP-1 (+9.8%) and lower MMP-1/TIMP-1 ratio (+11.9%; P < 0.041). Higher hs-cTnT levels at baseline correlated significantly with an increase in relative wall thickness (+23.1%) and LV mass index (+18.3%) during follow-up (P < 0.035).Conclusions: We identified a set of biomarkers predicting adverse changes in LV structure and function over time. Circulating biomarkers reflecting LV stiffness, injury and collagen composition might improve the identification of subjects at risk for subclinical cardiac maladaptation." @default.
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- W2950482783 date "2019-07-01" @default.
- W2950482783 modified "2023-10-18" @default.
- W2950482783 title "CIRCULATING BIOMARKERS PREDICTING LONGITUDINAL CHANGES IN LEFT VENTRICULAR STRUCTURE AND FUNCTION IN A GENERAL POPULATION" @default.
- W2950482783 doi "https://doi.org/10.1097/01.hjh.0000570432.84974.e9" @default.
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