Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950483362> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2950483362 abstract "The first total synthesis of (+)-astrophylline (2) has been achieved, starting from readily available enantiomerically pure (+)-(1R,4S)-4-hydroxycyclopent-2-enyl acetate (11). A novel ruthenium-catalyzed ring-closing ring-opening ring-closing metathesis of carbocyclic olefins of general type 5 was the key step, providing the stereochemically well-defined bis-piperidyl skeleton of the target molecule. A [2,3]-Wittig-Still rearrangement of 9 was also employed as the critical transformation in the stereocontrolled generation of the 1,2-trans configuration of the cyclopentene intermediate 6c. Our early synthetic efforts toward 1,2-trans cyclopentene derivatives of type 6, as well as the synthetic pathway to an optimized 13-step total synthesis of 2 (12% overall yield), are reported." @default.
- W2950483362 created "2019-06-27" @default.
- W2950483362 creator A5019124109 @default.
- W2950483362 creator A5032846636 @default.
- W2950483362 date "2003-08-12" @default.
- W2950483362 modified "2023-10-02" @default.
- W2950483362 title "Total Synthesis of (+)-Astrophylline." @default.
- W2950483362 cites W2136727502 @default.
- W2950483362 doi "https://doi.org/10.1002/chin.200332158" @default.
- W2950483362 hasPublicationYear "2003" @default.
- W2950483362 type Work @default.
- W2950483362 sameAs 2950483362 @default.
- W2950483362 citedByCount "0" @default.
- W2950483362 crossrefType "journal-article" @default.
- W2950483362 hasAuthorship W2950483362A5019124109 @default.
- W2950483362 hasAuthorship W2950483362A5032846636 @default.
- W2950483362 hasConcept C134121241 @default.
- W2950483362 hasConcept C153914509 @default.
- W2950483362 hasConcept C161790260 @default.
- W2950483362 hasConcept C178790620 @default.
- W2950483362 hasConcept C185592680 @default.
- W2950483362 hasConcept C191897082 @default.
- W2950483362 hasConcept C192562407 @default.
- W2950483362 hasConcept C21951064 @default.
- W2950483362 hasConcept C24292678 @default.
- W2950483362 hasConcept C2777811443 @default.
- W2950483362 hasConcept C2778593322 @default.
- W2950483362 hasConcept C2780378348 @default.
- W2950483362 hasConcept C35753019 @default.
- W2950483362 hasConcept C44138296 @default.
- W2950483362 hasConcept C44228677 @default.
- W2950483362 hasConcept C521977710 @default.
- W2950483362 hasConcept C555196967 @default.
- W2950483362 hasConcept C71240020 @default.
- W2950483362 hasConceptScore W2950483362C134121241 @default.
- W2950483362 hasConceptScore W2950483362C153914509 @default.
- W2950483362 hasConceptScore W2950483362C161790260 @default.
- W2950483362 hasConceptScore W2950483362C178790620 @default.
- W2950483362 hasConceptScore W2950483362C185592680 @default.
- W2950483362 hasConceptScore W2950483362C191897082 @default.
- W2950483362 hasConceptScore W2950483362C192562407 @default.
- W2950483362 hasConceptScore W2950483362C21951064 @default.
- W2950483362 hasConceptScore W2950483362C24292678 @default.
- W2950483362 hasConceptScore W2950483362C2777811443 @default.
- W2950483362 hasConceptScore W2950483362C2778593322 @default.
- W2950483362 hasConceptScore W2950483362C2780378348 @default.
- W2950483362 hasConceptScore W2950483362C35753019 @default.
- W2950483362 hasConceptScore W2950483362C44138296 @default.
- W2950483362 hasConceptScore W2950483362C44228677 @default.
- W2950483362 hasConceptScore W2950483362C521977710 @default.
- W2950483362 hasConceptScore W2950483362C555196967 @default.
- W2950483362 hasConceptScore W2950483362C71240020 @default.
- W2950483362 hasLocation W29504833621 @default.
- W2950483362 hasOpenAccess W2950483362 @default.
- W2950483362 hasPrimaryLocation W29504833621 @default.
- W2950483362 hasRelatedWork W1981560473 @default.
- W2950483362 hasRelatedWork W2016486259 @default.
- W2950483362 hasRelatedWork W2084564885 @default.
- W2950483362 hasRelatedWork W2949122965 @default.
- W2950483362 hasRelatedWork W2950542658 @default.
- W2950483362 hasRelatedWork W2952122892 @default.
- W2950483362 hasRelatedWork W2952500882 @default.
- W2950483362 hasRelatedWork W3023261378 @default.
- W2950483362 hasRelatedWork W4246046581 @default.
- W2950483362 hasRelatedWork W1781808265 @default.
- W2950483362 isParatext "false" @default.
- W2950483362 isRetracted "false" @default.
- W2950483362 magId "2950483362" @default.
- W2950483362 workType "article" @default.