Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950489885> ?p ?o ?g. }
- W2950489885 abstract "Significance Li–Fraumeni syndrome is a rare disorder caused by germline TP53 mutations, predisposing patients to early-onset cancers, including osteosarcoma (OS). Here we demonstrate that strong expression of SFRP2, a reported WNT antagonist, in OS patient samples correlates with poor survival and that SFRP2 overexpression suppresses normal osteoblast differentiation, promotes OS features, and facilitates angiogenesis via autocrine and paracrine mechanisms in an induced pluripotent stem cell disease model. We show that these SFRP2-mediated phenotypes are canonical WNT/β-catenin independent and are mediated through induction of oncogenes such as FOXM1 and CYR61. We further demonstrate that inhibition of SFRP2, FOXM1, or CYR61 represses tumorigenesis. Our data suggest that inhibition of SFRP2 should be explored clinically as a strategy for treatment patients with p53 mutation-associated OS." @default.
- W2950489885 created "2019-06-27" @default.
- W2950489885 creator A5006705223 @default.
- W2950489885 creator A5013573755 @default.
- W2950489885 creator A5026375867 @default.
- W2950489885 creator A5028794948 @default.
- W2950489885 creator A5033678712 @default.
- W2950489885 creator A5035424850 @default.
- W2950489885 creator A5039924892 @default.
- W2950489885 creator A5044006040 @default.
- W2950489885 creator A5047959665 @default.
- W2950489885 creator A5052259323 @default.
- W2950489885 creator A5054239132 @default.
- W2950489885 creator A5058745924 @default.
- W2950489885 creator A5061728175 @default.
- W2950489885 creator A5078463147 @default.
- W2950489885 creator A5083380528 @default.
- W2950489885 date "2018-11-01" @default.
- W2950489885 modified "2023-10-15" @default.
- W2950489885 title "Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism" @default.
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