FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950495320> ?p ?o ?g. }

• W2950495320 endingPage "9" @default.
• W2950495320 startingPage "3" @default.
• W2950495320 abstract "Objectives Recent studies have identified vaginal bacterial taxa associated with increased HIV risk. A possible mechanism to explain these results is that individual taxa differentially promote cervicovaginal inflammation. This study aimed to explore relationships between concentrations of bacteria previously linked to HIV acquisition and vaginal concentrations of proinflammatory cytokines and chemokines. Methods In this cross-sectional analysis, concentrations of 17 bacterial taxa and four proinflammatory cytokines (interleukin (IL)-1β, IL-6, IL-10 and tumour necrosis factor alpha (TNFα)) and two proinflammatory chemokines (IL-8 and interferon gamma-induced protein 10) were measured in vaginal swabs collected from 80 HIV-uninfected women. Cytokine and chemokine concentrations were compared between women with bacterial concentrations above or below the lower limit of detection as determined by quantitative PCR for each taxon. Principal component analysis was used to create a summary score for closely correlated bacteria, and linear regression analysis was used to evaluate associations between this score and increasing concentrations of TNFα and IL-1β. Results Detection of Dialister micraerophilus (p=0.01), Eggerthella sp type 1 (p=0.05) or Mycoplasma hominis (p=0.03) was associated with higher TNFα concentrations, and detection of D. micraerophilus (p<0.01) , Eggerthella sp type 1 (p=0.04) , M. hominis (p=0.02) or Parvimonas sp type 2 (p=0.05) was associated with significantly higher IL-1β concentrations. Seven bacterial taxa ( D. micraerophilus , Eggerthella sp type 1, Gemella asaccharolytica, Sneathia sp, Megasphaera sp, M. hominis and Parvimonas sp type 2) were found to be highly correlated by principal component analysis (eigenvalue 5.24, explaining 74.92% of variability). Linear regression analysis demonstrated associations between this principal component and concentrations of TNFα (β=0.55, 95% CI 0.01 to 1.08; p=0.048) and IL-1β (β=0.96, 95% CI 0.19 to 1.74; p=0.016). Conclusions This study provides evidence that several highly correlated vaginal bacterial taxa may influence vaginal cytokine and chemokine concentrations. These results suggest a mechanism where the presence of specific bacterial taxa could influence HIV susceptibility by increasing vaginal inflammation." @default.
• W2950495320 created "2019-06-27" @default.
• W2950495320 creator A5017816114 @default.
• W2950495320 creator A5026703630 @default.
• W2950495320 creator A5032142932 @default.
• W2950495320 creator A5033445246 @default.
• W2950495320 creator A5034462800 @default.
• W2950495320 creator A5048323364 @default.
• W2950495320 creator A5048579207 @default.
• W2950495320 creator A5050988457 @default.
• W2950495320 creator A5059998858 @default.
• W2950495320 creator A5061366174 @default.
• W2950495320 creator A5063617127 @default.
• W2950495320 creator A5075328638 @default.
• W2950495320 creator A5077476398 @default.
• W2950495320 creator A5084874518 @default.
• W2950495320 creator A5085389729 @default.
• W2950495320 creator A5091143050 @default.
• W2950495320 date "2019-06-13" @default.
• W2950495320 modified "2023-10-03" @default.
• W2950495320 title "Associations between vaginal bacteria implicated in HIV acquisition risk and proinflammatory cytokines and chemokines" @default.
• W2950495320 cites W1456189684 @default.
• W2950495320 cites W1474461326 @default.
• W2950495320 cites W1855030145 @default.
• W2950495320 cites W1868667984 @default.
• W2950495320 cites W1919603305 @default.
• W2950495320 cites W1968205810 @default.
• W2950495320 cites W1979180175 @default.
• W2950495320 cites W2022111190 @default.
• W2950495320 cites W2036951019 @default.
• W2950495320 cites W2062876702 @default.
• W2950495320 cites W2072527215 @default.
• W2950495320 cites W2072997280 @default.
• W2950495320 cites W2082992817 @default.
• W2950495320 cites W2088968901 @default.
• W2950495320 cites W2102946609 @default.
• W2950495320 cites W2105053076 @default.
• W2950495320 cites W2112059343 @default.
• W2950495320 cites W2126758324 @default.
• W2950495320 cites W2127934824 @default.
• W2950495320 cites W2131684347 @default.
• W2950495320 cites W2144678913 @default.
• W2950495320 cites W2145866317 @default.
• W2950495320 cites W2163488022 @default.
• W2950495320 cites W2293730450 @default.
• W2950495320 cites W2571049130 @default.
• W2950495320 cites W2575620371 @default.
• W2950495320 cites W2784439478 @default.
• W2950495320 cites W2794315486 @default.
• W2950495320 cites W2904121990 @default.
• W2950495320 doi "https://doi.org/10.1136/sextrans-2018-053949" @default.
• W2950495320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6920574" @default.
• W2950495320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31197065" @default.
• W2950495320 hasPublicationYear "2019" @default.
• W2950495320 type Work @default.
• W2950495320 sameAs 2950495320 @default.
• W2950495320 citedByCount "18" @default.
• W2950495320 countsByYear W29504953202020 @default.
• W2950495320 countsByYear W29504953202021 @default.
• W2950495320 countsByYear W29504953202022 @default.
• W2950495320 countsByYear W29504953202023 @default.
• W2950495320 crossrefType "journal-article" @default.
• W2950495320 hasAuthorship W2950495320A5017816114 @default.
• W2950495320 hasAuthorship W2950495320A5026703630 @default.
• W2950495320 hasAuthorship W2950495320A5032142932 @default.
• W2950495320 hasAuthorship W2950495320A5033445246 @default.
• W2950495320 hasAuthorship W2950495320A5034462800 @default.
• W2950495320 hasAuthorship W2950495320A5048323364 @default.
• W2950495320 hasAuthorship W2950495320A5048579207 @default.
• W2950495320 hasAuthorship W2950495320A5050988457 @default.
• W2950495320 hasAuthorship W2950495320A5059998858 @default.
• W2950495320 hasAuthorship W2950495320A5061366174 @default.
• W2950495320 hasAuthorship W2950495320A5063617127 @default.
• W2950495320 hasAuthorship W2950495320A5075328638 @default.
• W2950495320 hasAuthorship W2950495320A5077476398 @default.
• W2950495320 hasAuthorship W2950495320A5084874518 @default.
• W2950495320 hasAuthorship W2950495320A5085389729 @default.
• W2950495320 hasAuthorship W2950495320A5091143050 @default.
• W2950495320 hasBestOaLocation W29504953202 @default.
• W2950495320 hasConcept C13373296 @default.
• W2950495320 hasConcept C164027704 @default.
• W2950495320 hasConcept C203014093 @default.
• W2950495320 hasConcept C2776914184 @default.
• W2950495320 hasConcept C2779952448 @default.
• W2950495320 hasConcept C71924100 @default.
• W2950495320 hasConcept C86803240 @default.
• W2950495320 hasConcept C89423630 @default.
• W2950495320 hasConceptScore W2950495320C13373296 @default.
• W2950495320 hasConceptScore W2950495320C164027704 @default.
• W2950495320 hasConceptScore W2950495320C203014093 @default.
• W2950495320 hasConceptScore W2950495320C2776914184 @default.
• W2950495320 hasConceptScore W2950495320C2779952448 @default.
• W2950495320 hasConceptScore W2950495320C71924100 @default.
• W2950495320 hasConceptScore W2950495320C86803240 @default.
• W2950495320 hasConceptScore W2950495320C89423630 @default.
• W2950495320 hasIssue "1" @default.
• W2950495320 hasLocation W29504953201 @default.
• W2950495320 hasLocation W29504953202 @default.

• next